NCT07464223Active, not recruiting
MRI Assessment of Pancreatic Fat Changes and Islet Function Recovery After Bariatric Surgery in Obese Patients
A Longitudinal Study Based on MRI to Evaluate the Changes of Pancreatic Fat and the Recovery of Pancreatic Function in Obese Patients After Bariatric Surgery
Source: ClinicalTrials.gov · Last updated 12 Mar 2026
Brief summary (registry, in English)
This study evaluates changes in pancreatic fat and recovery of pancreatic function in obese patients undergoing laparoscopic sleeve gastrectomy (LSG), a weight-loss surgery. Obesity can cause fat to accumulate in the pancreas, which may impair insulin production and lead to type 2 diabetes. This study uses magnetic resonance imaging (MRI) to measure pancreatic fat before and after surgery to understand how weight loss affects pancreatic function. About 50 obese patients (BMI \> 32 kg/m²) aged 16-60 years who are scheduled for LSG will be enrolled. Participants will undergo MRI scans of the pancreas and blood tests before surgery and at 1, 3, and 6 months after surgery. The MRI uses a safe, non-invasive technique called Dixon imaging to measure fat content in different parts of the pancreas (head, body, and tail). Blood tests will measure fasting glucose, insulin, C-peptide, and HbA1c to assess pancreatic function. The study aims to determine whether reduction in pancreatic fat after weight-loss surgery is associated with improved insulin secretion and reduced insulin resistance. This information may help doctors better understand how bariatric surgery improves metabolic health and guide postoperative patient management. Participation involves no additional risk beyond routine clinical care. All MRI scans and blood tests are part of standard postoperative monitoring for bariatric surgery patients.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 6 Mar 2026
- Start date
- 1 Sept 2024
- Primary completion date
- 30 Apr 2026
- Lead sponsor
- yu li，MD
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07464223
What you commit to
- Study type: Observational
- Planned participants: 50
- From 1 Sept 2024 to the primary completion date, 30 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous major gastrointestinal surgery
- Poor compliance or self-control, unable to follow dietary guidance after surgery
Other illness
- Diagnosed gastric or duodenal ulcer
- Gastrointestinal diseases associated with malabsorption
- Other diseases causing abnormal pancreatic function
Other
- Secondary obesity
- BMI \< 32 kg/m²
- Unable to complete follow-up visits
- Contraindications for MRI examination
- Pregnancy or lactation
Who the study is looking for
- Age between 16 and 60 years
- BMI \> 32 kg/m²
- Preoperative auxiliary examination supports diagnosis of pancreatic fat infiltration
- Willing to undergo pancreatic MRI examination
- Previous attempts at other weight loss methods have been ineffective
- Complete medical records available
- Voluntary signed informed consent
- Scheduled to undergo laparoscopic sleeve gastrectomy (LSG) at Qingdao University Affiliated Hospital
Age in the registry: 16 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Qingdao University Affiliated Hospital Coordinator of this site? Confirm its status | Qingdao | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.