NCT07466602Recruiting
cfDNA Methylation for Liver Cancer Recurrence Detection
Clinical Study on the Combined Detection of Plasma GNB4 and Riplet Gene Methylation for Monitoring Primary Liver Cancer Recurrence
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
Through follow-up testing of patients with primary liver cancer who underwent hepatectomy, liver transplantation, ablation therapy, or transarterial chemoembolization (TACE), a blinded comparative trial was conducted at each monitoring site. This trial evaluated the combined methylation detection kit for GNB4 and Riplet genes (fluorescent PCR method) against the clinical reference standard (defined as the physician's comprehensive diagnosis based on clinical guidelines and other criteria). The study evaluated the clinical performance of the assay in diagnosing primary liver cancer recurrence and validated the clinical efficacy of methylation detection kits for monitoring recurrence after primary liver cancer treatment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 26 Feb 2026
- Start date
- 2 Sept 2025
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Wuhan Ammunition Life-tech Co., Ltd
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07466602
What you commit to
- Study type: Observational
- Planned participants: 500
- From 2 Sept 2025 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent other malignant tumors;
- Ineligible for hepatectomy, liver transplantation, ablation, or TACE therapy;
- Negative methylation status prior to treatment.
Who the study is looking for
- Primary liver cancer
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Coordinator of this site? Confirm its status | Wuhan | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.