NCT07466823Completed
Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
Multiple sclerosis (MS) is a chronic neurological disease frequently associated with spasticity, which may lead to functional limitations and reduced quality of life. Although spasticity is common in MS, detailed descriptions of upper and lower extremity spasticity patterns are limited. A better understanding of spasticity patterns may help improve individualized rehabilitation and treatment planning. The aim of this study is to classify upper and lower extremity spasticity patterns in patients with multiple sclerosis and to investigate their association with quality of life. Adult patients with MS and clinical spasticity will be recruited from a tertiary care outpatient clinic. Spasticity will be evaluated using the Modified Ashworth Scale, and extremity postures will be recorded to define spasticity patterns. Functional performance will be assessed using the Timed 25-Foot Walk Test and the 9-Hole Peg Test. The impact of spasticity on quality of life will be evaluated using the Patient-Reported Impact of Spasticity Measure (PRISM). This prospective cross-sectional study is designed to provide a systematic description of spasticity patterns in patients with multiple sclerosis and to examine their relationship with functional outcomes and quality of life.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 77 (actual)
- First submitted
- 27 Feb 2026
- Start date
- 1 Jan 2026
- Primary completion date
- 30 Aug 2026
- Lead sponsor
- Marmara University
- Diseases
- Multiple sclerosis
- NCT number
- NCT07466823
What you commit to
- Study type: Observational
- Participants enrolled: 77
- From 1 Jan 2026 to the primary completion date, 30 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Botulinum toxin type A injection within the previous 3 months
- Previous surgical treatment for upper extremity spasticity
Other illness
- Presence of orthopedic, rheumatologic, or neurological conditions affecting movement other than multiple sclerosis
- Presence of cognitive impairment
Other
- Bone deformities affecting the upper extremity
- Inability or unwillingness to provide informed consent
Who the study is looking for
- Diagnosis of multiple sclerosis according to the 2024 McDonald criteria
- Age ≥ 18 years
- Presence of clinical spasticity defined as Modified Ashworth Scale score ≥ 1 in at least one joint
- Ability to understand study procedures and provide informed consent
- Absence of significant cognitive impairment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Marmara Üniversitesi Tıp Fakültesi, Istanbul, Maltepe 34854 Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.