NCT07467434Recruiting
FOLFIRINOX Induction Chemotherapy for Synchronous Liver Metastases
Multicenter Cohort Study of Mid/Lower Rectal Cancer With Resectable Synchronous Liver Metastases Treated With FOLFIRINOX Induction Chemotherapy
Source: ClinicalTrials.gov · Last updated 9 Jun 2026
Brief summary (registry, in English)
SYNCHRONOX is a multicenter cohort (retrospective then prospective) intending to include 550 patients with mid or low rectal adenocarcinoma (pMMR, T3-T4 and/or N+) and resectable synchronous liver metastases, treated upfront with at least two cycles of induction FOLFIRINOX chemotherapy. The primary objective is to determine, at 18 months, the R0 resection rate of both tumor sites (rectum and liver), while secondary objectives focus on 3 year overall and progression free survival, radiological and pathological responses, postoperative morbidity and mortality, and comparison of the different surgical strategies after FOLFIRINOX.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 550 (estimated)
- First submitted
- 8 Mar 2026
- Start date
- 1 May 2026
- Primary completion date
- 1 Nov 2030
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Colorectal cancer
- NCT number
- NCT07467434
What you commit to
- Study type: Observational
- Planned participants: 550
- From 1 May 2026 to the primary completion date, 1 Nov 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Induction chemotherapy with FOLFIRINOX of less than 2 courses
Age
- Minor under the age of 18.
Other
- Presence of extrahepatic metastases
Who the study is looking for
- Adult subjects aged 18 years and older
- Adenocarcinoma of the middle and/or lower rectum pMMR T3, T4, and/or N+
- Resectable synchronous liver metastases
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Digestive Surgery Department, Bicêtre University Hospital AP-HP Coordinator of this site? Confirm its status | Le Kremlin-Bicêtre | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.