NCT07469384Recruiting
Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways
Sensory Contributions to Third Visual Pathway Dysfunction in Schizophrenia: Correlation and Causation
Source: ClinicalTrials.gov · Last updated 13 Mar 2026
Brief summary (registry, in English)
This study investigates the ability of transcranial direct current stimulation (tDCS) applied over the motion processing area of the brain (area MT) to improve face emotion recognition (FER) ability. tDCS is a type of non-invasive brain stimulation in which low level currents are applied over the scalp to influence underlying brain function. In schizophrenia, impaired ability to detect facial motion has been shown to contribute to impaired FER, which, in turn, leads to difficulties in social cognition and poor social outcome. The study will use both fMRI and EEG to measure brain function while participants view moving dot and dynamic face stimuli. Analyses will compare changes in fMRI and EEG activity in individuals receiving active vs. sham stimulation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 20 Feb 2026
- Start date
- Feb 2026
- Primary completion date
- Apr 2030
- Lead sponsor
- Nathan Kline Institute for Psychiatric Research
- Diseases
- Schizophrenia
- NCT number
- NCT07469384
What you commit to
- Study type: Interventional
- Planned participants: 120
- From Feb 2026 to the primary completion date, Apr 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindication to MRI (e.g. metal implants, claustrophobia, pregnancy)
Other illness
- Significant neurological illness or history of significant head trauma
- Unstable physical illness or significant auditory/visual deficits that might interfer
- Contraindications to tDCS including metal implant, pacemaker, history of seizure, traumatic brain injury or stroke
- Has a history of an illness, disease, condition injury, or disability which, in the opinion of the principal investigator, may interfere with the completion of all study requirements per protocol, impact the quality of the data, or the validity of the study results, including unstable physical illness, significant neurological illness, significant head trauma
- Moderate or greater DSM-5 current substance use disorder, defined based on the presence of 4 or more of 11 substance use criteria within the past 12 months. In addition, individuals for whom substance use leads to not being able to perform work, home or school activities
Other
- Significant risk for suicide
Who the study is looking for
- Male or female subject, age 18-55
- Competent and willing to sign informed consent
- No more than moderately ill
- SCID DSM-5 diagnosis of Sz/SzAff
- WAIS IQ \>70
- Does not meet current criteria for DSM-5 defined substance abuse or dependence or have a history of diagnosis within past 6 months
- On medication within clinically approved range
- Does not meet criteria for another DSM-5 disorder other than those judged to be minor (e.g. simple phobia)
Age in the registry: 18 years to 55 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nathan Kline Institute Coordinator of this site? Confirm its status | Orangeburg | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.