NCT07470593Recruiting
Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.
Prospective Longitudinal Observational Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.
Source: ClinicalTrials.gov · Last updated 17 Mar 2026
Brief summary (registry, in English)
Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events. However, its long-term effectiveness is limited by progressive loss of graft function. Currently, there is no standardized method to detect early dysfunction of the transplanted islets. This study aims to determine whether a parameter derived from continuous glucose monitoring (CGM), Time in Tight Range (70-140 mg/dL), is associated with pancreatic islet grafts function. The study hypothesis is that a decrease in Time in Tight Range reflects early loss of islet graft function.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 36 (estimated)
- First submitted
- 9 Mar 2026
- Start date
- 15 Dec 2025
- Primary completion date
- 15 Dec 2029
- Lead sponsor
- University Hospital, Strasbourg, France
- Diseases
- Type 1 diabetes
- NCT number
- NCT07470593
What you commit to
- Study type: Observational
- Planned participants: 36
- From 15 Dec 2025 to the primary completion date, 15 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- Patient refusal to wear continuous glucose monitoring device
Other
- Pancreatic islet autotransplantation
- Inability to provide informed consent (e.g., difficulties understanding study information)
- Patient under judicial protection (safeguard of justice)
- Patient under guardianship or curatorship
Who the study is looking for
- ≥18 years old
- Insulin-dependent diabetes (type 1 diabetes, secondary to chronic pancreatitis, MODY, cystic fibrosis)
- Patient who has completed a full cycle of pancreatic islet transplantation, either:
- Islet Transplantation Alone (ITA), or
- Islet After Kidney (IAK), or
- Simultaneous Islet Kidney (SIK), with \>10,000 IEQ/kg of recipient body weight, or \<10,000 IEQ/kg but having achieved insulin independence
- Patient who has provided consent for reuse of their data for this research
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopitaux Universitaires de Strasbourg Coordinator of this site? Confirm its status | Strasbourg | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.