NCT07473518Recruiting
Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
Source: ClinicalTrials.gov · Last updated 16 Mar 2026
Brief summary (registry, in English)
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2550 (estimated)
- First submitted
- 11 Mar 2026
- Start date
- 30 Jul 2025
- Primary completion date
- 30 Jul 2026
- Lead sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Diseases
- Thyroid cancer, Childhood cancers
- NCT number
- NCT07473518
What you commit to
- Study type: Observational
- Planned participants: 2550
- From 30 Jul 2025 to the primary completion date, 30 Jul 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- For the group of oncologic patients who underwent radiotherapy:
- Patients transferred to another center before completing 4 years of follow-up after radiotherapy at the Pediatric Unit of IRCCS AOU Bologna, without having received a diagnosis of thyroid cancer.
- For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC:
Other
- None.
Who the study is looking for
- For the group of oncologic patients who underwent radiotherapy:
- Radiotherapy for an oncologic condition performed between January 1, 1999, and December 31, 2018;
- Age at the time of radiotherapy \< 18 years;
- Follow-up of at least 4 years conducted at the Endocrine-Metabolic Diseases Program, Pediatric Unit, IRCCS AOU Bologna;
- Obtained informed consent
- For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC:
- No history of exposure to ionizing radiation;
- No specific risk factors for DTC (autoimmune thyroiditis, familial forms, genetic syndromes);
- Thyroid ultrasound performed between January 1, 1999, and December 31, 2018, at the Nuclear Medicine Unit of IRCCS AOU Bologna;
- Age at the time of the thyroid ultrasound \< 18 years;
- Obtained informed consent
Age in the registry: 10 years to 43 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UO Medicina Nucleare - IRCCS Azienda Ospedaliero-Universitaria di Bologna Coordinator of this site? Confirm its status | Bologna | Italy | Recruiting |
| UOC Pediatria - IRCCS Azienda Ospedaliero-Universitaria di Bologna Coordinator of this site? Confirm its status | Bologna | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.