NCT07473596Completed
Predictors and Long-term Incidence of In-stent Restenosis After Chronic Total Occlusion Percutaneous Coronary Intervention
Predictors and Long-term Incidence of In-stent Restenosis After Chronic Total Occlusion Percutaneous Coronary Intervention: a Cohort Study
Source: ClinicalTrials.gov · Last updated 16 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to describe the long-term (≥ 3 years) patency of coronary artery stents following chronic total occlusion percutaneous coronary intervention (CTO PCI). The main questions it aims to answer are: * What is the incidence of in-stent restenosis after CTO PCI? * What are patient-, lesion-, and procedure-related factors associated with an increased risk of in-stent restenosis after CTO PCI?
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 294 (actual)
- First submitted
- 25 Nov 2025
- Start date
- 16 Jan 2023
- Primary completion date
- 6 Feb 2025
- Lead sponsor
- Lauri Mansikkaniemi
- Diseases
- Coronary artery disease
- NCT number
- NCT07473596
What you commit to
- Study type: Interventional
- Participants enrolled: 294
- From 16 Jan 2023 to the primary completion date, 6 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing alcohol or drug abuse
- Coronary artery bypass surgery (CABG) after CTO PCI
- invasive coronary angiography performed less than 6 months prior to the surveillance imaging date
- CCTA results were reviewed by the interventional cardiologists of the study and ICA was offered to patients with:
Other illness
- Malignancy with ongoing diagnostics or poor prognosis
- Considerable functional impairment in activities of daily living
- Presence of a clinically significant psychiatric disorder
- Presence of a memory disorder or other clinically significant cognitive impairment
Other
- Target lesion revascularisation or angiographically verified ISR after CTO PCI
- Estimated glomerular filtration rate ≤40 ml/min
- ISR or an inconclusive finding within the CTO stent.
- Anginal symptoms with either ≥ 50 % stenosis or an inconclusive finding in any native coronary artery or within a non-CTO stent.
Criteria the registry did not label
- Study inclusion criteria were the following:
- Successful CTO PCI with a drug-eluting stent
- Primary procedure minimum of 3 years prior to study date
- Of the included patients, CTO stent patency surveillance imaging with CCTA was conducted according to the following criteria. Patients were consecutive and prospectively recruited.
- Surveillance imaging inclusion criteria
- Surviving patients ≤ 80 years old at the time of surveillance imaging
- Communication in Finnish, Swedish or English
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Helsinki University Central Hospital Coordinator of this site? Confirm its status | Helsinki | Finland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.