NCT07474571Recruiting
Evaluation of Musculoskeletal Aging and Related Disorders Via Advanced Clinical Imaging
A Comprehensive Evaluation of Musculoskeletal Aging and Degenerative Pathologies Using Multi-modal Clinical Imaging and Quantitative Analysis.
Source: ClinicalTrials.gov · Last updated 19 Mar 2026
Brief summary (registry, in English)
Study Overview This clinical research focuses on the development and validation of a multimodal artificial intelligence (AI) platform designed for the automated diagnosis and precise staging of two major musculoskeletal conditions: Osteoporosis (OP) and Osteoarthritis (OA). By integrating diverse clinical imaging data, the study aims to provide a more objective and standardized approach to assessing bone and joint degeneration. Technological Core: Intelligent Staging Traditional diagnosis often relies on manual interpretation, which can lead to inter-observer variability. This study employs deep learning and multimodal imaging to: For Osteoporosis: Automatically quantify bone mineral density and micro-architectural changes to determine the stage of bone loss and evaluate fracture risk. For Osteoarthritis: Identify subtle radiological markers such as joint space narrowing and osteophyte formation to categorize the severity of joint degeneration according to international staging standards (e.g., Kellgren-Lawrence scale). Why This Matters Early Intervention: By identifying early-stage changes in bone density and joint integrity, clinicians can implement preventive treatments before significant disability occurs. Standardized Care: The intelligent diagnostic model provides a "digital second opinion," ensuring consistent staging across different healthcare settings. Efficiency: The automated workflow reduces the workload of radiologists while maintaining high diagnostic accuracy. Ethical Compliance The study is conducted at Peking University People's Hospital under the supervision of the Institutional Review Board (Approval No. 2026PHB097-001). It strictly adheres to international ethical standards, including the Declaration of Helsinki and Good Clinical Practice (GCP) guidelines, to ensure patient data privacy and safety.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 11 Mar 2026
- Start date
- 1 Nov 2005
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- Peking University People's Hospital
- Diseases
- Osteoporosis
- NCT number
- NCT07474571
What you commit to
- Study type: Observational
- Planned participants: 2000
- From 1 Nov 2005 to the primary completion date, 1 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pathological History: Patients with a history of prior pathological fractures.
- Recent Treatment: Patients who have undergone radiotherapy or chemotherapy within the past six months.
Other illness
- Malignancy: Patients seeking treatment or diagnosed with bone tumors or other systemic malignancies.
- Medication History: Patients with a history of long-term steroid use, which may significantly affect bone density and joint structure.
Other
- Data Quality: Patients whose imaging data is of insufficient quality for AI analysis or lacks clear clinical diagnostic "gold standard" references (e.g., missing DXA results for osteoporosis staging).
Who the study is looking for
- Age: Adults aged at least 18 years.
- Gender: No gender restrictions; both male and female participants are eligible.
- Imaging Data: Participants must have completed relevant clinical imaging scans of skeletal sites, including but not limited to X-ray, CT (plain scan), or MRI (plain scan).
- Anatomical Integrity: The skeletal structure of the target area must be free from congenital or acquired deformities.
- Absence of Implants: No internal fixation materials or orthopedic implants in the skeletal areas being assessed.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| - Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.