NCT07476274Recruiting
Nosocomial Pneumonia After Coronary Artery Bypass Grafting
The Impact of Nosocomial Pneumonia on the Outcome and Prognosis of Stable Coronary Artery Disease After Coronary Artery Bypass Grafting
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
Observational studies of patients with coronary artery bypass grafting, associated with an unfavorable cardiopulmonary prognosis for at least one year after surgery. This is Prospective, cohort, unblinded, observational comparable single center clinical trial. To compare the clinical, laboratory (including complete blood count, metabolic panel, and specific cardiac, inflammatory, infectious, and endothelial biomarkers), functional (ECG, echocardiography, ultrasound, spirometry, cardiopulmonary exercise testing), and radiological (chest X-ray/CT) phenotypes in patients with coronary artery bypass grafting with and without non-ventilator-associated postoperative, nosocomial pneumonia; to identify the factors of early and 1-years cardiopulmonary prognosis. Increased risk of cardiovascular outcomes is related with the circulatory arrest, artificial circulation, perioperative trauma and respiratory complications of the postoperative period associating to the different severity and duration of the systemic inflammatory response, immune status disorders, hemostasis disorder, endothelial dysfunction, external respiration dysfunction, anatomic and functional disorders in the heart and lungs. Individual predictors of an unfavorable prognosis can be determined at the stage of before and just after surgery to conduct personalized prevention. This study aimed to compare the clinical, laboratory (including complete blood count, metabolic panel, and specific cardiac, inflammatory, infectious, and endothelial biomarkers), functional (ECG, echocardiography, ultrasound, spirometry, cardiopulmonary exercise testing), and radiological (chest X-ray/CT) phenotypes in patients after coronary artery bypass grafting with and without non-ventilator-associated postoperative nosocomial pneumonia; to identify the factors of early and 1-years cardiopulmonary prognosis.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 11 Mar 2026
- Start date
- 1 Oct 2024
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
- Diseases
- Coronary artery disease
- NCT number
- NCT07476274
What you commit to
- Study type: Observational
- Planned participants: 80
- From 1 Oct 2024 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Age 18 years and older.
- Myocardial revascularization for CAD via CABG during the current hospitalization, in accordance with the indications defined by the ESC/EACTS Guidelines on Myocardial Revascularization \[DOI: 10.1093/eurheartj/ehy394\].
- Successful transfer from the intensive care unit to a general ward after surgery.
- One or more of the risk factor for nosocomial pneumonia \[doi: 10.15829/1560-4071-2024-6094\].
- Signed informed consent for participation in the study.
- Pre-operative Exclusion Criteria:
- Acute coronary syndrome within the last 1 month.
- Combined surgical intervention for infective endocarditis.
- Combined valve surgery.
- Concomitant pulmonary disease requiring respiratory support prior to surgery.
- Presence of a tracheostomy.
- Participation in another clinical trial at the time of potential inclusion or within the preceding 3 months.
- Diagnosis of malignant neoplasms within the last 5 years.
- Life duration of less than 1 year.
- HIV infection.
- Peri-operative Exclusion Criteria:
- Ventilator-Associated Pneumonia (VAP).
- Acute Myocardial Infarction after CABG and before inclusion.
- Acute Stroke after CABG and before inclusion.
- Pulmonary after CABG and before inclusion.
- Pulmonary Edema after CABG and before inclusion.
- Acute Respiratory Distress Syndrome (ARDS) after CABG and before inclusion.
- Pneumothorax requiring drainage after CABG and before inclusion.
- Delirium after CABG and before inclusion.
- Chronic Kidney Disease (CKD) Stage 4-5 / Acute Kidney Injury requiring renal replacement therapy or chronic dialysis.
- Any perioperative complication requiring the patient's return to the intensive care unit or prolonging the ICU stay beyond 48 hours.
- Any other active infectious process at a different site.
- Novel Coronavirus Infection (COVID-19).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cardiology Research Institute of Tomsk NRMC Coordinator of this site? Confirm its status | Tomsk | Russia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.