NCT07477067Recruiting
Exercise and Protein Efficiency in T2D
Exercise Impact on Dietary Protein Efficiency in Older Adults With Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 29 Apr 2026
Brief summary (registry, in English)
In this randomized controlled trial, 30 older adults (aged\> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 1 Dec 2025
- Start date
- 9 Feb 2026
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- University of Illinois at Urbana-Champaign
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07477067
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 9 Feb 2026 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation.
Other illness
- Untreated hypothyroidism, epilepsy, medications that affect vasoactivity, possibility of pregnancy, and any neurological, cardiovascular, or musculoskeletal disease that precludes exercise testing.
Lab values
- Uncontrolled diabetes (evidence of HbA1c \> 10%, prescription of insulin)
Other
- Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening
- Statins
Who the study is looking for
- At least 65 years old
- Body mass index: 25-40 kg/m\^2
- Female: Waist to hip ratio \>0.8
- Male: Waist to hip ratio \>1.0
- Free from structured exercise during the prior 6 months (mo) weight stable for the prior 6 months
- T2D group:
- -Diagnosed by a physician with elevated glycosylated hemoglobin (HbA1c) \>6.5%
- Control group:
- -Normoglycemic with HbA1c levels not exceeding 5.6% and fasting blood glucose levels below or equal to 99 mg/dL (5.5mmol)
Age in the registry: 65 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Freer Hall - University of Illinois Coordinator of this site? Confirm its status | Urbana | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.