NCT07479017Not yet recruiting
Characterization of Platelet Molecular Profiles in ALS for the Identification of Specific Diagnostic Biomarkers - A Pilot Study
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
The search for diagnostic biomarkers that can be used routinely is a major challenge to manage Amyotrophic lateral sclerosis (ALS) in order to characterize the pathophysiology and accelerate the management of the disease. Some non-specific biomarkers have been proposed (Neurofilaments, TDP-43) but their diagnostic value remains controversial. This study aims to identify ALS-specific platelet biomarkers using targeted and untargeted multi-omic approaches, in order to enable differential diagnosis between ALS and other motor neuron diseases.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 60 (estimated)
- First submitted
- 3 Mar 2026
- Start date
- 1 Apr 2026
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- University Hospital, Tours
- Diseases
- ALS (motor neurone disease)
- NCT number
- NCT07479017
What you commit to
- Study type: Observational
- Planned participants: 60
- From 1 Apr 2026 to the primary completion date, 31 Aug 2027
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with oral or injectable anticoagulants, antiplatelet agents (EXCEPT aspirin at the maximum authorized dosage of 160 mg per day)
Other illness
- Uncontrolled diabetes
Other
- Genetic variants associated with ALS
- Pregnant or breastfeeding women
- Persons deprived of their liberty by judicial or administrative decision
- Persons subject to legal protection measures: guardianship or curatorship
- Opposition to data processing
Who the study is looking for
- Patients with ALS:
- Men or women aged 18 to 75
- ALS diagnosed according to the El Escorial criteria
- ALS diagnosis less than 3 months ago
- Onset of symptoms defined as the time when muscle weakness was first observed by the patient less than 2 years ago
- Controls with another motor neuron disease:
- Men or women aged 18 to 75
- Diagnosis of motor neuron disease \< 3 months
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital, Limoges Coordinator of this site? Confirm its status | Limoges | France | Unknown status |
| University hospital, Lyon Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
| university hospital, Tours Coordinator of this site? Confirm its status | Tours | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.