NCT07479095Recruiting
Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma
Source: ClinicalTrials.gov · Last updated 20 Mar 2026
Brief summary (registry, in English)
This study evaluates whether a 7-day ketogenic dietary regimen before 2-\[18F\]FDG PET/CT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET/CT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET/CT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 13 Mar 2026
- Start date
- 3 Jul 2025
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- Fondazione del Piemonte per l'Oncologia
- Diseases
- Lung cancer
- NCT number
- NCT07479095
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 3 Jul 2025 to the primary completion date, 30 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Other malignancies that are progressing or required active treatment within the previous 3 years.
Other illness
- Renal failure.
- Type 1 diabetes mellitus.
- Serious or unstable medical, psychiatric, or substance use disorders that could interfere with study participation.
Other
- Not suitable for prolonged imaging procedures.
- Pancreatitis.
- Severe dyslipidemia.
- Pregnancy or breastfeeding.
- Refusal to participate
Who the study is looking for
- Written informed consent.
- Age 18 years or older.
- CT evidence of a lung nodule suspicious for LPA or lung biopsy positive for LPA.
- Target nodule diameter at least 10 mm.
- ECOG performance status 0 to 2.
- Willingness and ability to adhere to a controlled ketogenic diet for 7 days.
- Ability to comply with study procedures and visit schedule.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fondazione del Piemonte per l'Oncologia- IRCCS Istituto di Candiolo, Candiolo, Turin 10060 Coordinator of this site? Confirm its status | Candiolo | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.