NCT07479277Recruiting
Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC
A Multicenter, Randomized, Parallel-Group Trial Evaluating Progel Platinum Added to Mechanical Stapling Versus Mechanical Stapling Alone in Patients Undergoing VATS Upper or Lower Lobectomy for Non-Small Cell Lung Cancer
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 160 (estimated)
- First submitted
- 9 Mar 2026
- Start date
- 27 Feb 2026
- Primary completion date
- 27 Feb 2027
- Lead sponsor
- Fondazione del Piemonte per l'Oncologia
- Diseases
- Lung cancer
- NCT number
- NCT07479277
What you commit to
- Study type: Interventional
- Planned participants: 160
- From 27 Feb 2026 to the primary completion date, 27 Feb 2027
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Induction radiochemotherapy or chemo-immunotherapy
- Sleeve resection or extended resection involving other lobes/chest wall/pericardium, etc.
- Redo surgery
Other illness
- Renal insufficiency
Lab values
- Albumin intolerance/allergy
Other
- Severe COPD: GOLD 3 or higher
- Use of sealants/adhesives other than the study approach
- Expected extensive pleural adhesions
Who the study is looking for
- Age ≥18 years
- Written informed consent
- Planned VATS upper or lower lobectomy for NSCLC
- Minimally invasive thoracoscopic approach
- Middle lobectomy excluded
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ospedale centrale di Bolzano, Chirurgia Toracica e Vascolare Coordinator of this site? Confirm its status | Bolzano | Italy | Not yet recruiting |
| Unità di Chirurgia Toracica Oncologica Coordinator of this site? Confirm its status | Candiolo | Italy | Recruiting |
| Azienda Ospedaliero-Universitaria Careggi Coordinator of this site? Confirm its status | Florence | Italy | Not yet recruiting |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| Irccs Ismett Coordinator of this site? Confirm its status | Palermo | Italy | Not yet recruiting |
| Azienda Ospedaliera Universitaria Pisana Coordinator of this site? Confirm its status | Pisa | Italy | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.