NCT07480265Recruiting
Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension
Relationship Between Elevated Homocysteine Levels and Early Diastolic Dysfunction in Newly Diagnosed Hypertensive Patients
Source: ClinicalTrials.gov · Last updated 24 Mar 2026
Brief summary (registry, in English)
This prospective single-center observational study aims to evaluate the relationship between elevated plasma homocysteine levels and early echocardiographic abnormalities in patients with newly diagnosed essential hypertension. Adult patients diagnosed with essential hypertension within the previous 6 months will undergo clinical assessment, ambulatory blood pressure monitoring, electrocardiography, laboratory testing, and comprehensive transthoracic echocardiography including diastolic function assessment and strain analysis when image quality is adequate. Participants will be classified according to plasma homocysteine level using, and patients with elevated and normal homocysteine levels will be compared with respect to diastolic dysfunction and left ventricular and left atrial global longitudinal strain parameters. Clinical, laboratory, and echocardiographic data will also be used to develop a machine-learning based model for prediction of H-type hypertension.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 6 Mar 2026
- Start date
- 2 Jun 2025
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Necmettin Erbakan University
- Diseases
- High blood pressure
- NCT number
- NCT07480265
What you commit to
- Study type: Observational
- Planned participants: 500
- From 2 Jun 2025 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Acute coronary syndrome within the previous 6 months
- Major surgery within the previous 6 months
Other illness
- Resistant hypertension
- Secondary hypertension
- Known heart failure
- Pulmonary hypertension
- Congenital heart disease
- Moderate or severe valvular heart disease
- Chronic kidney disease
- Known systemic conditions that may significantly affect plasma homocysteine levels
Other
- Atrial fibrillation or atrial flutter
- Anemia
- Current folate, vitamin B12, or vitamin B6 supplementation or treatment
- Inadequate echocardiographic image quality for strain analysis
Who the study is looking for
- Adults aged 18 years or older
- Newly diagnosed essential hypertension within the previous 6 months
- Ability and willingness to provide informed consent
- Availability for clinical evaluation, laboratory testing, ambulatory blood pressure monitoring, electrocardiography, and transthoracic echocardiography
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Necmettin Erbakan University Meram Faculty of Medicine Coordinator of this site? Confirm its status | Konya | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.