NCT07480317Not yet recruiting
TIS for Brain Network Modulation and Clinical Efficacy in Parkinson's Disease
Mechanism of Temporal Interference Stimulation on Brain Networks and Its Long-term Clinical Efficacy in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 24 Mar 2026
Brief summary (registry, in English)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients. Temporal interference stimulation (TIS) is a novel non-invasive technique that can target deep brain structures like the globus pallidus internus (GPi) by using high-frequency electric fields. This study aims to evaluate the clinical value and underlying mechanisms of TIS in PD patients. The research is divided into two phases: Phase A investigates the immediate regulatory effects of 130 Hz and 40 Hz TIS on brain networks using concurrent fMRI-TIS. Phase B is a randomized, double-blind, sham-controlled trial to assess the long-term efficacy and safety of a 2-week TIS intervention on both motor and non-motor symptoms. The results will help clarify how TIS modulates deep brain networks and its potential as a non-invasive therapy for PD.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- First submitted
- 14 Mar 2026
- Start date
- 20 Mar 2026
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- Jiangsu Province Nanjing Brain Hospital
- Diseases
- Parkinson disease
- NCT number
- NCT07480317
What you commit to
- Study type: Interventional
- Planned participants: 75
- From 20 Mar 2026 to the primary completion date, 31 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- MRI contraindications, such as implanted DBS electrodes, cardiac pacemakers, or other metal implants.
- Significant cognitive impairment (MoCA score \< 24) or severe psychiatric symptoms.
- History of epilepsy or structural brain lesions, including severe cerebral atrophy or cerebrovascular disease.
Other
- Severe head tremors that would interfere with MRI scanning quality.
Who the study is looking for
- Diagnosed with Parkinson's Disease according to the Movement Disorder Society (MDS) clinical diagnostic criteria.
- Hoehn \& Yahr Stage I-III (mild to moderate severity).
- Aged 45 to 65 years.
- Right-handed. Stable medication regimen for at least 1 hour before Phase A fMRI sessions and agreement to maintain a stable dosage during the 2-week Phase B intervention (unless clinically necessary).
- Able to provide informed consent by the participant or a legal guardian.
Age in the registry: 45 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nanjing Brain Hospital (Affiliated Brain Hospital of Nanjing Medical University) Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.