NCT07480343Enrolling by invitation
5-Year Postoperative Outcomes of Patients Who Completed the CREST Study
FIVE-YEAR POSTOPERATIVE OUTCOMES IN PATIENTS WITH OPEN-ANGLE GLAUCOMA WHO UNDERWENT BIO-INTERVENTIONAL UVEOSCLERAL OUTFLOW ENHANCEMENT SURGERY: LONG-TERM OBSERVATIONAL FOLLOW-UP FROM THE CREST STUDY (THE CREST-XT STUDY)
Source: ClinicalTrials.gov · Last updated 21 Jul 2026
Brief summary (registry, in English)
This study is designed to collect clinical data at 3, 4, and 5 years postoperatively for participants who completed the CREST Study without having secondary IOP-lowering surgery in the study eye(s).
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 250 (estimated)
- First submitted
- 29 Dec 2025
- Start date
- 15 Sept 2025
- Primary completion date
- 31 Dec 2030
- Lead sponsor
- Iantrek, Inc.
- Diseases
- Glaucoma
- NCT number
- NCT07480343
What you commit to
- Study type: Observational
- Planned participants: 250
- From 15 Sept 2025 to the primary completion date, 31 Dec 2030
- 10 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Secondary surgical intervention for long-term IOP control in the study eye(s)
Other illness
- Systemic disease that, in the opinion of the Investigator, would put participant's health at risk and/or prevent completion of required study visits
Other
- Early termination from CREST
Who the study is looking for
- Diagnosis of open-angle glaucoma (OAG) in the study eye(s), including pigmentary and pseudoexfoliative glaucoma, at the time of CREST enrollment
- Completed participation in CREST
- Provide signed written consent using the Institutional Review Board (IRB)/Ethics Committee (EC) approved study-specific informed consent form (ICF)
- Ability, comprehension, and willingness to follow study instructions
Sex: All · Does not accept healthy volunteers
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CREST-XT Site 07 Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| CREST-XT Site 03 Coordinator of this site? Confirm its status | Cape Coral | United States | Unknown status |
| CREST-XT Site 12 Coordinator of this site? Confirm its status | Chevy Chase | United States | Unknown status |
| CREST-XT Site 04 Coordinator of this site? Confirm its status | Crossville | United States | Unknown status |
| CREST-XT Site 10 Coordinator of this site? Confirm its status | DeLand | United States | Unknown status |
| CREST-XT Site 01 Coordinator of this site? Confirm its status | Fort Washington | United States | Unknown status |
| CREST-XT Site 16 Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| CREST-XT Site 05 Coordinator of this site? Confirm its status | Newport Beach | United States | Unknown status |
| CREST-XT Site 13 Coordinator of this site? Confirm its status | Rockville | United States | Unknown status |
| CREST-XT Site 11 Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.