NCT07483580Completed
LEG-UP Feasibility Study: Elevated Leg Positioning For Acute Moderate Ischemic Stroke
Elevated Leg Positioning For Acute Moderate Ischemic Stroke: The LEG-UP Randomized Feasibility Study
Source: ClinicalTrials.gov · Last updated 24 Mar 2026
Brief summary (registry, in English)
Augmentation of penumbral perfusion through nonpharmacological hemodynamic interventions such as patient positioning may offer a pragmatic approach to improve outcomes in acute ischemic stroke (AIS). This study aimed to assess the feasibility and safety of elevated leg positioning (ELP) in AIS, and to generate preliminary estimates of effect sizes to inform the design of a future definitive randomized trial.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 50 (actual)
- First submitted
- 16 Mar 2026
- Start date
- 1 May 2025
- Primary completion date
- 19 Sept 2025
- Lead sponsor
- Bonifacio C. Pedreogsa II
- Diseases
- Stroke
- NCT number
- NCT07483580
What you commit to
- Study type: Interventional
- Participants enrolled: 50
- From 1 May 2025 to the primary completion date, 19 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Planned or completed intravenous thrombolysis and/or endovascular therapy.
- Prior stroke with significant residual neurological deficit (mRS ≥2).
Other illness
- Evidence of intracranial hemorrhage on neuroimaging.
- Alternative stroke etiologies (e.g., cardioembolism, non-atherosclerotic arteriopathies).
- Serious systemic illness (e.g., significant hepatic or renal insufficiency, active malignancy).
- History of intracerebral hemorrhage within the preceding 12 months.
- Any possible contraindication to ELP (e.g., active vomiting, pneumonia, uncontrolled heart failure).
- Any other condition deemed inappropriate for participation by the investigators.
Other
- Decreased level of consciousness (NIHSS item 1a ≥1).
- Planned carotid or intracranial revascularization within 3 months.
- Participation in another clinical trial within the preceding 3 months.
- Pregnancy or lactation.
Who the study is looking for
- Age ≥18 years.
- Acute ischemic stroke (AIS) confirmed by cranial computed tomography (CT) or magnetic resonance (MR) imaging.
- Time from onset (symptom onset or last known well) to enrollment of ≤24 hours.
- Moderate neurological deficit (National Institutes of Health Stroke Scale \[NIHSS\] score of 6-16).
- Probable large artery atherosclerosis (LAA )etiology based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria (confirmed by cranial CT or MR angiography and carotid duplex ultrasonography performed on admission).
- Evidence of unilateral stenosis or occlusion of the internal carotid artery (ICA) or the M1 or proximal M2 segment of the middle cerebral artery (MCA) corresponding to the presumed culprit artery.
- Functional independence prior to stroke (modified Rankin Scale \[mRS\] score ≤1).
- Written informed consent signed by the patient or their legally authorized representative.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Jose R. Reyes Memorial Medical Center Coordinator of this site? Confirm its status | Manila | Philippines | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.