NCT07484867Completed
Effect of CYP2D6*10 Gene Mutation on Perioperative Precision Analgesia of Oxycodone in Elderly Patients
Effect of CYP2D6 on Perioperative Analgesia of Oxycodone in Elderly Patients
Source: ClinicalTrials.gov · Last updated 12 May 2026
Brief summary (registry, in English)
The purpose of this prospective study was to determine the effect of CYP2D6 gene polymorphism on perioperative analgesia of oxycodone in elderly patients, and to assign the CYP2D6 phenotype according to the genotype, and to use inhibitors for pain control of phenotype conversion. The significance is to accurately guide the perioperative analgesia of oxycodone in elderly patients, and to more effectively avoid toxicity and adverse reactions.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 100 (actual)
- First submitted
- 4 Jun 2024
- Start date
- 1 Jan 2025
- Primary completion date
- 15 Jun 2025
- Lead sponsor
- Henan Provincial People's Hospital
- NCT number
- NCT07484867
What you commit to
- Study type: Observational
- Participants enrolled: 100
- From 1 Jan 2025 to the primary completion date, 15 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- ( 1 ) Patients with severe liver and kidney dysfunction ( severe liver dysfunction : ALT, AST, ALP, total bilirubin, etc. One of them \> 2 times the upper limit of normal value. Severe renal dysfunction : creatinine \> 2 times the upper limit of normal ) ; ( 2 ) Identify / suspect abuse or long-term use of narcotic sedative analgesics ; ( 3 ) Reoperation within 3 months ; ( 4 ) Patients with contraindications or allergies to test drugs and other narcotic drugs ; ( 5 ) CYP2D6 inhibitors or inducers were used within 30 days ; ( 6 ) Have a history of smoking, heavy drinking or drug use.
Other
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Who the study is looking for
- ( 1 ) Age ≥ 60 years old ; ( 2 ) ASA grade I \~ II ; ( 3 ) Receiving radical resection of lung cancer ; ( 4 ) BMI was 18.5 \~ 29.9 kg / m2 \[ BMI = weight ( Kg ) / height ( m ) 2 \] ( 2013 US ' Adult Overweight and Obesity Management Guidelines ' ).
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Age in the registry: 60 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Henan Provincial People's Hospital Coordinator of this site? Confirm its status | Zhengzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.