NCT07485387Recruiting
Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort
Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort That is Associated With the Einstein Aging Study
Source: ClinicalTrials.gov · Last updated 20 Mar 2026
Brief summary (registry, in English)
The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea. The main questions it aims to answer are: Does daily psychological stress measured in real-time affect short-term and long-term cognitive function in older adults? Do pro-inflammatory cytokines (such as CRP, IL-6, IL-10, and TNF-α) mediate the relationship between emotional stress and cognitive decline? How do social support and social isolation influence cognitive function and inflammatory biomarkers over time? Participants will: Complete baseline surveys assessing depression, cognitive function, and personal characteristics Use a smartphone app to answer brief surveys about their emotions, cognitive performance, and social interactions 1-6 times daily for two weeks Wear a Galaxy Watch to track sleep quality, heart rate, and physical activity Provide blood samples for inflammatory biomarker analysis Return for follow-up assessments at 6 months and 1 year This study is part of an international collaboration to establish a Korean cohort comparable to the U.S. Einstein Aging Study, with the aim of developing culturally tailored dementia prevention strategies.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 180 (estimated)
- First submitted
- 20 Jan 2026
- Start date
- 1 Apr 2025
- Primary completion date
- 30 Apr 2027
- Lead sponsor
- Korea University
- Diseases
- Depression, Alzheimer disease
- NCT number
- NCT07485387
What you commit to
- Study type: Observational
- Planned participants: 180
- From 1 Apr 2025 to the primary completion date, 30 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently undergoing cancer treatment or received chemotherapy within the past 6 months
Other illness
- Diagnosis of dementia at baseline
- Inability to ambulate or psychiatric conditions that prevent survey participation
Other
- Severe visual or hearing impairments that prevent participation in psychological assessments
- Illiteracy that prevents participation in cognitive testing
- Less than 80% compliance with the 2-day preliminary EMA protocol (one additional attempt allowed after re-training)
- Current alcohol or substance abuse
Who the study is looking for
- Adults aged 60 or older residing in the Republic of Korea
- Samsung Galaxy smartphone users capable of using smartphone applications
- Sufficient cognitive ability to understand and follow research instructions (MMSE score of 21 or above)
- For individuals who do not meet the cognitive criteria, those who understand the study procedures and provide informed consent along with their legal guardian
Age in the registry: 60 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Korea University Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.