NCT07486401Recruiting
Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)
Randomised Controlled Trial Of Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)
Source: ClinicalTrials.gov · Last updated 20 Mar 2026
Brief summary (registry, in English)
The aim of this study is to evaluate usual care versus biomarker-directed care (using blood eosinophil counts) for the management of asthma patients in primary care setting. The study hypothesizes that BEC is a valuable biomarker that can guide asthma treatment, and result in reduction in asthma exacerbations, better symptom control and improvement in quality of life compared to usual arm in mild to moderate asthma patients in the primary care setting. Researchers would compare using blood eosinophil count guided to usual care to see if biomarker-directed asthma treatment and management
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 240 (estimated)
- First submitted
- 5 Dec 2025
- Start date
- Dec 2025
- Primary completion date
- Dec 2028
- Lead sponsor
- National Healthcare Group Polyclinics
- Diseases
- Asthma
- NCT number
- NCT07486401
What you commit to
- Study type: Interventional
- Planned participants: 240
- From Dec 2025 to the primary completion date, Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of long-term immunosuppression, LTRA receptor antagonist (Montelukast) and Theophylline or long-term oral steroids
- Use of oral, rectal, or parenteral glucocorticoid within 30 days and/or depot parenteral glucocorticoid within 12 weeks prior to recruitment
Other illness
- History of life-threatening asthma requiring intubation or intensive care unit admission
- Presence of other known causes of eosinophilia besides asthma (e.g. parasitic infection), based on physician's discretion and investigation as per clinical practice and suspicion
- Known diagnosis of Chronic Obstructive Pulmonary Disease, Interstitial lung disease or bronchiectasis
- Any significant disease or disorder (eg. Cardiovascular, pulmonary other than asthma, gastrointestinal, hepatic, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the investigator, may either put the patient at risk because of participation in the study, or may influence the results of the study, or the patient's ability to participate in the study
Other
- Severe asthma or difficult to treat asthma
- Current use of beta-blocking agents including eye-drops
- Current enrolment in other interventional clinical trial for asthma
- Female subjects who are pregnant or planning pregnancy during the study period
- Planned travel outside of the country for ≥16 consecutive weeks during the study
- Investigator's assessment of poor capability of following study instructions or comply with study procedures
Who the study is looking for
- Singaporeans or Singapore Permanent Residents
- Patients aged ≥21 to 65 years old
- Physician diagnosed asthma for duration of at least 4 weeks
- On or will be initiated on Global Initiative for Asthma (GINA) 2025 step 1-3) treatment
- No asthma exacerbations\* in the preceding 4 weeks before randomisation
- Able and willing to attend study appointments approximately every 4-monthly over a 1-year period
- Able to provide informed consent
- Stable cardiovascular status (i.e. controlled hypertension, no active symptoms of heart disease or arrhythmias) \*Exacerbations are defined as worsening of asthma symptoms requiring systemic corticosteroid for 3 or more days, emergency department visit, or hospitalization
Age in the registry: 21 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Healthcare Group Polyclinics Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.