NCT07487090RecruitingPhase 2
Fasted vs. Fed State Exercise
Fasted vs. Fed State Exercise for Cardiovascular Health and Weight Loss
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
Although many medications exist for both heart disease and obesity, cost, lack of access for all people, side effects and the desire for a more natural solution have left many people seeking lifestyle treatments such as exercise. Scientists know that exercise is highly beneficial for heart health. When exercise also produces weight loss, these benefits are much improved. Although using exercise to treat or prevent heart disease / obesity is recommended, not all people respond well. Some see significant weight loss and health improvements while others see little changes. For these reasons, new strategies surrounding the use and design of an exercise program are needed. One such strategy could be performing aerobic exercise before breakfast (fasted exercise). When exercising fasted, food/energy stores are low, and one relies on stored body fat for energy. This may help heart health and weight loss. This has never been tested in a program long enough to see such changes. This study will, for the first time, assess the effects of a 16-week aerobic exercise program performed fasted compared to after eating. Outcomes will include blood fats, blood pressure, fat-burning abilities and weight loss. Starting an exercise program can also make people to eat more. This limits the success of exercise. The study will also evaluate ways fasted exercise could change eating, as it possible that fasted exercise could also cause people to eat more, which would limit weight loss and health improvements.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 13 Mar 2026
- Start date
- 5 Jan 2026
- Primary completion date
- Jul 2027
- Lead sponsor
- Arkansas Colleges of Health Education
- Diseases
- Obesity
- NCT number
- NCT07487090
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 40
- From 5 Jan 2026 to the primary completion date, Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking medications or supplements that are known to influence energy expenditure,
- Currently taking weight loss drugs
- Have had a previous weight loss surgery
Other illness
- Currently diagnosed with Diabetes
- Currently diagnosed with heart disease (Heart failure, uncontrolled hypertension, uncontrolled hypercholesterolemia, Coronary heart disease)
Other
- Currently exercising more than once per week
- Currently dieting for weight loss
Who the study is looking for
- Aged 18-59
- BMI 25-45
- Healthy enough to exercise
Age in the registry: 18 years to 59 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Arkansas Colleges of Health Education Research Institure Health and Wellness Center Coordinator of this site? Confirm its status | Fort Smith | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.