NCT07487428Recruiting
CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLL
An Interventional Study of Dietary Effects on Immune Function, Metabolism and Disease Activity in Early-Stage Chronic Lymphocytic Leukemia
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to investigate whether a short-term (4-week) whole-food, plant-based (WFPB) diet has an effect on metabolism, immune function, and disease activity in early-stage chronic lymphocytic leukemia (CLL). The main questions the study aims to answer are: * Does a WFPB diet influence disease progression? * How do CLL cells and other immune cell types respond to a WFPB diet in terms of metabolism and signaling? Researchers will examine whether a WFPB diet can affect absolute lymphocyte counts in participants' blood and what metabolic or functional changes occur within the CLL cells. Participants will: * Switch to a WFPB diet for 4 weeks following an introductory session with a certified dietary instructor. * Visit the clinic before starting the diet and again after 14 and 28 days for blood draws and to provide stool samples. * Keep a diary of all foods and drinks consumed during the week prior to and throughout the study period.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 22 Sept 2025
- Start date
- 1 Jan 2024
- Primary completion date
- 1 Jun 2028
- Lead sponsor
- Technical University of Munich
- Diseases
- Chronic lymphocytic leukaemia
- NCT number
- NCT07487428
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 1 Jan 2024 to the primary completion date, 1 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking lipid-lowering medications (e.g. statins)
Other illness
- Insulin-dependent diabetes
Other
- Emergency interventions
- Patients that already follow a WFPB or vegan diet
- Progression of CLL that implicates need for treatment
- Body mass index (BMI) \<20 And if in the opinion of the investigator there are any concerns regarding the ability of the patient to complete the study safely.
Who the study is looking for
- Confirmed CLL diagnosis
- No previous treatments (watch and wait)
- Willingness to comply to a whole-food plant-based diet for 4 weeks
- Willingness to participate in a total of 3 blood drawings
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Klinikum der Technischen Universität München (Klinikum rechts der Isar) Coordinator of this site? Confirm its status | München | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.