NCT07488910Not yet recruitingPhase 4
Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological, Psychological and Combined Treatment of Depression
Veränderungen Dynamischer Symptom-Netzwerke Unter Pharmakologischer, Psychotherapeutischer Und Kombinierter Behandlung Bei Depression (DYNDET)
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
This study investigates how antidepressant pharmacotherapy, cognitive-behavioral therapy, or their combination modulate the temporal dynamics and connectivity of depressive symptom networks. Using intensive longitudinal ecological momentary assessment data, the trial examines treatment-specific changes in symptom interactions. By applying network-based analytic approaches, the study aims to elucidate differential and potentially complementary mechanisms of change across treatment modalities. Findings may contribute to more informed and individualized treatment strategies for major depressive disorder.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 23 Feb 2026
- Start date
- Feb 2026
- Primary completion date
- Jan 2028
- Lead sponsor
- Goethe University
- Diseases
- Depression
- NCT number
- NCT07488910
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 90
- From Feb 2026 to the primary completion date, Jan 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- concurrent psychotherapeutic treatment
Other illness
- bipolar disorder,
- substance use disorder
- severe medical or neurological illness
- conditions that may interfere with fMRI
Other
- severe depressive episode
- acute suicidality,
- psychotic depression
- insufficient german language skills
Who the study is looking for
- Depressive disorder (mild to moderate symptom severity)
- 18-65 years
- must own a smartphone with internet access
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinical Psychology and Psychotherapy Coordinator of this site? Confirm its status | Frankfurt | Germany | Unknown status |
| Department of Psychiatry, Psychosomatics and Psychotherapy Coordinator of this site? Confirm its status | Frankfurt | Germany | Unknown status |
| Department of Psychiatry and Psychotherapy Coordinator of this site? Confirm its status | Marburg | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.