NCT07489924Active, not recruitingPhase 4
Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis.
Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs. Probiotic (Lactobacillus Reuteri Prodentis) of Porphyromonas Gingivalis in Patients With Periodontal Disease and Type 2 Diabetes Mellitus in Colima. a Randomized Non-inferiority Clinical Trial.
Source: ClinicalTrials.gov · Last updated 24 Mar 2026
Brief summary (registry, in English)
This randomized non-inferiority clinical trial aims to evaluate the microbiological effect of 0.12% chlorhexidine and 0.05% cetylpyridinium vs. probiotics (Lactobacillus reuteri Prodentis) on Porphyromonas gingivalis in patients with periodontal disease and diabetes mellitus in Colima, where molecular biology tests such as qPCR will be performed at the end, before and after treatment in each of the groups.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 18 Mar 2026
- Start date
- 8 Jan 2023
- Primary completion date
- 31 Jul 2025
- Lead sponsor
- Universidad de Colima
- Diseases
- Type 2 diabetes
- NCT number
- NCT07489924
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 20
- From 8 Jan 2023 to the primary completion date, 31 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Inability to cooperate.
- Antibiotic treatment within the last 3 months.
- Soft tissue pathologies not related to periodontal disease.
- Elimination Criteria:
- Failure to complete the study.
Other
- Insufficient or non-extracted DNA sample.
- Indication of antibiotics/fluoxetine during the intervention.
Who the study is looking for
- • Previous diagnosis of controlled type 2 diabetes mellitus.
- Periodontal disease (≥2 quadrants affected; probing depth ≥4 mm; bleeding on probing \>10%).
- Patients affiliated with the Unidad de Salud Zona Oriente (IMSS-BIENESTAR).
- Signed informed consent.
Age in the registry: 35 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Colima Coordinator of this site? Confirm its status | Colima | Mexico | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.