NCT07490925Recruiting
Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS
Application of Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With Acute Respiratory Distress Syndrome Caused by Pneumonia
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
To verify whether the transpulmonary pressure-guided mechanical ventilation strategy can reduce right ventricular involvement, especially the incidence of acute cor pulmonale (ACP), in patients with moderate to severe ARDS induced by pneumonia compared with the currently widely used right ventricular protective mechanical ventilation strategy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 180 (estimated)
- First submitted
- 17 Mar 2026
- Start date
- Mar 2026
- Primary completion date
- Mar 2028
- Lead sponsor
- Beijing Chao Yang Hospital
- NCT number
- NCT07490925
What you commit to
- Study type: Interventional
- Planned participants: 180
- From Mar 2026 to the primary completion date, Mar 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Lung transplant recipient
- Already received salvage measures (iNO, ECMO, prone position, high-frequency oscillatory ventilation)
Other illness
- History of pulmonary hypertension caused by various reasons
- Severe arrhythmia
- High-risk factors for increased intracranial pressure (including intracranial hemorrhage, cerebral contusion, cerebral edema, intracranial space-occupying lesions, etc.)
- Active air leakage in the lungs (pneumothorax, mediastinal emphysema, bronchopleural fistula, air leakage from closed thoracic drainage tubes, etc.)
- Neuromuscular disease
- Severe liver failure
Lab values
- Contraindications to inserting an esophageal catheter (including recent esophageal injury or surgery, severe coagulopathy (platelets \< 5×10⁹/L or INR \> 4)
Other
- Invasive mechanical ventilation duration \> 48 hours
- BMI\>30kg/m2
- Pregnant and lactating women
- Participated in other ARDS-related studies within 30 days
Who the study is looking for
- Age ≥ 18 years old
- ARDS caused by pneumonia (New Global Definition of ARDS)
- PaO2/FiO2≤200mmHg
- Received invasive mechanical ventilation
- Sign the informed consent form
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Chao-Yang Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.