NCT07491484Recruiting
Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth
The Impact of Physical Functioning on Self-Reported Measures of Quality of Life in the ALS Patient Population at TidalHealth Peninsula Regional
Source: ClinicalTrials.gov · Last updated 24 Mar 2026
Brief summary (registry, in English)
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease in which motor neuron cells of the brain and spinal cord progressively degenerate and die. There is currently a lack of curative treatment for individuals that are diagnosed with ALS. Since treatment options are limited, researchers have placed greater emphasis on evaluating Quality-of-Life (QoL) as it offers perspective into the everyday life of the patient and is sensitive to changes over time. The goal of this longitudinal observational study is to learn more about what factors negatively impact an individual's QoL after they are diagnosed with ALS. Previous research has shown that an individual's level of physical functioning can negatively impact their quality of life, but this may not be the only factor. The main objectives this study are: 1. Assess if there is a statistically significant correlation between patient's functionality scores (ALSFRS-R) and quality of life scores (ALSAQ-40). 2. Determine how disease stage (King's Clinical Severity Staging System) affects correlation between functionality scores (ALSFRS-R) and quality of life scores (ALSAQ-40). Participants will complete a quality-of-life questionnaire (ALSAQ-40) every other time they present to their standard-of-care clinic visits for a period of two years. In parallel, with the functionality rating (ALSFRS-R) scores captured as standard-of-care at every clinic visit.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 10 Mar 2026
- Start date
- 3 Jul 2025
- Primary completion date
- Dec 2026
- Lead sponsor
- TidalHealth, Inc.
- Diseases
- ALS (motor neurone disease)
- NCT number
- NCT07491484
What you commit to
- Study type: Observational
- Planned participants: 30
- From 3 Jul 2025 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Unwilling or unable to comply with the study procedure, including the presence of any condition that is likely to affect the participant's ability to comply with study procedures.
Other
- Unable to read and understand English
Who the study is looking for
- Over the age of 18
- Have a diagnosis of Amyotrophic Lateral Sclerosis of Motor Neuron Disease
- Able to comprehend and willing to sign an informed consent form and comply with study procedures.
- Receiving care at TidalHealth Peninsula Regional Multidisciplinary ALS Clinic
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| TidalHealth Peninsula Regional, Inc. Coordinator of this site? Confirm its status | Salisbury | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.