NCT07491835Completed
Effect of Lower Doses of Colonic Nutrient Supplementation on Appetite Hormones and Food Intake in Obese Adults
The Effect of Nutrients on Regulating Appetite - a Dosing Study
Source: ClinicalTrials.gov · Last updated 25 Mar 2026
Brief summary (registry, in English)
Here are both updated sections: Brief Summary: The goal of this clinical trial is to learn if two different doses of dietary supplements delivered to the lower gut can reduce appetite and food intake in obese adults (men and women aged 18-60 with a BMI of 30-40 kg/m²). The main questions it aims to answer are: Does the dose of DIM and Perilla oil delivered to the colon affect circulating levels of appetite-suppressing hormones (PYY, GLP-1, ghrelin, GIP and 5-HT)? Does the dose of DIM and Perilla oil delivered to the colon affect total caloric food intake? Does the dose of DIM and Perilla oil delivered to the colon affect hunger and appetite perception? Researchers will compare a medium dose (250mg DIM + 1050mg Perilla oil) to a low dose (125mg DIM + 525mg Perilla oil) to see if both doses are effective at suppressing appetite and reducing food intake. Participants will: Fast from 20:00 h the evening before their study visit Attend a single study visit at the Wingate Institute Clinical Trials Unit, London Take 4 specially coated capsules (targeting the lower gut) at 08:00 and again at 12:00 Have blood samples taken every 30 minutes across 17 time points to measure hormone levels Complete hunger and appetite questionnaires (VAS) every 30 minutes from 08:00 to 16:00 Eat a standardised gender-adjusted breakfast (max 903 kcal) and lunch (max 1340 kcal)
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 16 (actual)
- First submitted
- 13 Mar 2026
- Start date
- 18 Oct 2023
- Primary completion date
- 11 Nov 2023
- Lead sponsor
- Queen Mary University of London
- Diseases
- Obesity
- NCT number
- NCT07491835
What you commit to
- Study type: Interventional
- Participants enrolled: 16
- From 18 Oct 2023 to the primary completion date, 11 Nov 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Major gut surgery involving removal of any part of the gastrointestinal tract
- Currently taking medication for Type 1 or Type 2 diabetes
- Currently taking medication for weight loss (e.g., semaglutide)
Other illness
- Known major bowel disease
Other
- BMI outside the range of 30-40 kg/m²
- Unable to understand English or provide informed consent
Who the study is looking for
- Aged 18 years or over
- BMI 30-40 kg/m²
- No prior bowel surgery
- Not taking medications for Type II diabetes
- Willing to consume standardised test meals
- Able to understand the study information sheet and instructions in English
- Able to provide written informed consent
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Wingate Institute of Neurogastroenterology Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.