NCT07492836Not yet recruiting
Hypofractionated Radiotherapy Plus Temozolamide in Patients Younger Than 70 Years With Glioblastoma
Prospective, Pilot Study to Evaluate Hypofractionated Radiotherapy Associated With Temozolomide in Patients Aged 18 to 70 Years With Glioblastoma (HypoGBM)
Source: ClinicalTrials.gov · Last updated 25 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the feasibility, safety and effectiveness of radiotherapy with fewer days of treatment and a higher dose of radiation each day in patients under 70 years of age diagnosed with a brain tumor known as glioblastoma.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 11 Mar 2026
- Start date
- Apr 2026
- Primary completion date
- Oct 2026
- Lead sponsor
- Hospital do Coracao
- Diseases
- Glioblastoma
- NCT number
- NCT07492836
What you commit to
- Study type: Interventional
- Planned participants: 10
- From Apr 2026 to the primary completion date, Oct 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients submitted to any type of previous radiotherapy in the cranial region;
- Contraindication to chemotherapy with temozolomide;
- Contraindications for performing magnetic resonance imaging (MRI), such as the use of implants or metallic prostheses;
Age
- Pregnant women or women of childbearing age who refuse to undergo the beta-HCG test before treatment and contraception during the intervention.
Other
- Multicentric tumors;
Who the study is looking for
- Initial histological diagnosis of glioblastoma
- Age \> 18 and \< 70 years;
- Karnofsky Performance Status \> 70%;
- Patient consent to participate in the study.
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.