NCT07492901Completed
Impact of Ligament of Marshall Resection on Atrial Fibrillation Occurrence in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 25 Mar 2026
Brief summary (registry, in English)
Background: 20-40% of patients with ischemic heart disease managed with coronary artery bypass grafting (CABG) surgeries face the risk of postoperative atrial fibrillation (POAF), which is a known hazardous outcome. Being a well-known arrhythmogenic pathway, surgical excision of the ligament of Marshall may, theoretically, lower the incidence of POAF. Aim: In this study, we aimed to assess the safety and efficacy of prophylactic LoM resection in preventing POAF after on-pump CABG (ON-CAB.). Methods: 220 patients at elevated risk for POAF undergoing elective ON-CAB were randomized to receive either standard CABG alone (n = 110) or adjunctive LoM resection (n = 110) in this multicenter, randomized, assessor- and patient-blinded study with unblinded surgeons. ECG-verified POAF occurring within seven days was the primary outcome. Mortality, use of resources, and pharmaceutical therapy were secondary outcomes.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 220 (actual)
- First submitted
- 4 Mar 2026
- Start date
- Jan 2024
- Primary completion date
- Nov 2025
- Lead sponsor
- Kasr El Aini Hospital
- Diseases
- Atrial fibrillation
- NCT number
- NCT07492901
What you commit to
- Study type: Interventional
- Participants enrolled: 220
- From Jan 2024 to the primary completion date, Nov 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of previous cardiac surgery.
- Concomitant cardiac procedures (e.g., valve surgery, surgical ablation for atrial fibrillation).
- Contraindications to anticoagulation or antiarrhythmic therapy.
Lab values
- Severe left ventricular systolic dysfunction (ejection fraction \<30%).
Other
- Preoperative atrial fibrillation requiring active treatment or long-term anticoagulation.
- Emergency or urgent CABG.
- Inability or unwillingness to provide informed consent.
Who the study is looking for
- Adults aged ≥18 years.
- Scheduled for elective on-pump coronary artery bypass grafting (CABG).
- Diagnosed with multivessel coronary artery disease or left main disease requiring surgical revascularization according to current guidelines.
- Classified as high risk for postoperative atrial fibrillation, defined as the presence of at least two of the following:
- Age ≥65 years
- Left atrial enlargement (anteroposterior diameter \>40 mm on transthoracic echocardiography)
- History of paroxysmal atrial fibrillation not requiring long-term anticoagulation
- Chronic obstructive pulmonary disease requiring regular pharmacological therapy
- Ability to provide written informed consent.
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Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cairo University Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
| Kasr Alainy Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.