NCT07492979Recruiting
Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy
Nordic-CSP - a Randomized Nordic Study - Is Conduction System Pacing Superior Compared to Conventional BIV-CRT in Reducing the Death or Heart Failure-related Hospitalization in Patients With Heart Failure and Bundle Branch Block?
Source: ClinicalTrials.gov · Last updated 28 Jul 2026
Brief summary (registry, in English)
The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1100 (estimated)
- First submitted
- 10 Feb 2026
- Start date
- Jun 2026
- Primary completion date
- Mar 2031
- Lead sponsor
- Copenhagen University Hospital, Rigshospitalet
- Diseases
- Heart failure
- NCT number
- NCT07492979
What you commit to
- Study type: Interventional
- Planned participants: 1100
- From Jun 2026 to the primary completion date, Mar 2031
- 5 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- treatment with a cardiac implantable electronic device (CIED) is contraindicated.
Other illness
- recent acute myocardial infarction (AMI)
Lab values
- Patients are excluded with regards to the MRI sub study if eGFR \> 35 ml/min, in case or contrast allergy or certain metal implants.
Age
- life expectancy \<2 years, patients in hemodialysis
Other
- coronary artery bypass graft (CABG) (\<3 months)
Who the study is looking for
- ≥18 years of age,
- LVEF ≤ 35%,
- NYHA Class II-IV (IV only outpatients),
- optimized in medical treatment (OMT)
- AND one of the following:
- . LBBB according to AHA/ACC/HRS Scientific Statement from 2009 and ≥130ms or
- LBBB-like intraventricular conduction delay (IVCD) \> 150ms or RV paced QRS and indication for upgrade to CRT (\> 40% RV pacing) OR
- ≥18 years of age,
- LVEF ≤ 40 %
- pacing indicated by AV-block and, thus, expected large percentage of ventricular pacing.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dept. of Cardiology, Aarhus University Hospital, Aarhus Coordinator of this site? Confirm its status | Aarhus | Denmark | Not yet recruiting |
| Rigshospitalet (Copenhagen University Hospital) Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
| Dept of Cardiology, Meilahti Hospital, Helsinki Coordinator of this site? Confirm its status | Helsinki | Finland | Not yet recruiting |
| Haukeland Universitetssykehus Coordinator of this site? Confirm its status | Bergen | Norway | Not yet recruiting |
| Sahlgrenska University Hospital Coordinator of this site? Confirm its status | Gothenburg | Sweden | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.