NCT07493915Recruiting
Precision Rehabilitation for Veterans With (HFpEF)
Precision Rehabilitation for Veterans With Heart Failure With Preserved Ejection Fraction (HFpEF)
Source: ClinicalTrials.gov · Last updated 25 Mar 2026
Brief summary (registry, in English)
This study is being completed because there is conflicting information regarding the value of monitored exercise in patients with heart failure with preserved ejection fraction (HFpEF). The purpose of this study is to collect baseline information necessary for researchers to pursue a larger study evaluating how monitored exercise performed during cardiac rehabilitation may improve heart health and the amount of oxygen delivered to the tissues during exercise. Researchers must first examine whether the facility is capable of supporting such a study and whether in a modest number of patients, there is no clear detrimental effect to exercise. Rather, there may be an important improvement that has been underestimated to date. Participation will require a time commitment for performing exercise 3 times per week for 12 weeks in addition to having a small amount of blood drawn twice. There will also be a specialized form of a stress test (cardiopulmonary exercise test; "CPET") with ultrasound imaging of the heart (echocardiography) completed twice.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 4 (estimated)
- First submitted
- 11 Apr 2025
- Start date
- 1 Jun 2023
- Primary completion date
- 9 Apr 2026
- Lead sponsor
- Columbia VA Health Care System
- Diseases
- Heart failure
- NCT number
- NCT07493915
What you commit to
- Study type: Observational
- Planned participants: 4
- From 1 Jun 2023 to the primary completion date, 9 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Acute ST segment elevation myocardial infarction (STEMI)
- Significant valvular or other non-coronary heart disease
- Any non-cardiac disease or condition that could influence myocardial function (e.g., collagen-vascular disease, history of cardiotoxic cancer chemotherapy, amyloid)
- Current accelerating angina, unstable angina, angina at rest, or NSTEMI within 3 months
- Chronic pulmonary disease requiring home oxygen or steroid therapy
Lab values
- Ejection Fraction \< 50%
- Anemia defined as Hgb \< 11.0 g/dl in males, 10 g/dl in females
- Significant non-CV organ disease: Chronic hepatic or renal disease (eGFR \< 25 mL/min/1.73m2)
Other
- Absence of LVH
- LV Dilation (LV end diastolic volume indexed to BSA \> 75 ml/m2)
- Any Segmental wall motion abnormality
- Inability to provide informed consent
- Inability to perform exercise
Who the study is looking for
- New York Heart Association Class II or III HF symptoms
- History of hypertension
- EF≥50%
- LVH confirmed by echocardiography, Cardiac CT, or Cardiac MR
- Diastolic dysfunction which must include ≥2 of the following:
- Average E/e'\>14
- Septal e'\<7 cm/s or Lateral e' \<10 cm/s
- TR velocity\> 2.8 m/s
- LA computed volume index \>34 mL/M2
- PCWP or LVEDP\>15
- Ability to participate in an exercise program as determined by a research, cardiology, or primary care provider
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Columbia VA Health Care System Coordinator of this site? Confirm its status | Columbia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.