NCT07494084RecruitingPhase 4

Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance

Source: ClinicalTrials.gov · Last updated 18 Sept 2026

Brief summary (registry, in English)

The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction. Chronic sleep loss is highly prevalent, affecting 1 in 3 adults in the US. Chronic sleep loss causes stress which induces insulin resistance and leads to obesity and type 2 diabetes. Many factors contribute to sleep loss including shift work, environmental disturbances, sleep/circadian disorders and comorbid medical and mental health conditions. Sleep loss increases the stress hormone cortisol in the evening and decreases daytime testosterone. Examining these hormones in a controlled laboratory environment under different sleep schedules may help researchers find solutions for adults experiencing negative health consequences related to chronic sleep loss.

Status (registry): Recruiting
Phase (registry): Phase 4
Study type: Interventional
Enrollment: 48 (estimated)
First submitted: 9 Mar 2026
Start date: Jul 2026
Primary completion date: Mar 2029
Lead sponsor: Washington State University
Diseases: Type 2 diabetes
NCT number: NCT07494084

What you commit to

Study type: Interventional · Phase 4
Planned participants: 48
From Jul 2026 to the primary completion date, Mar 2029
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

Must be between 18-45 years old.
Has a BMI of 18-25 kg/m2 stable weight over the previous 6 weeks.
Is physically and psychologically healthy (incl. regular menstrual cycles in women, no clinical disorders and/or illnesses). Women will be studied during the follicular phase of their menstrual cycle.
- Menstrual cycle criteria (using PMID 10941950) 18 to 25 years - Cycle variation ≤9 days 26 to 41 years - Cycle variation ≤7 days 42 to 45 years - Cycle variation ≤9 days
No current medical or drug treatment (to include steroids or hormones of any type including contraceptives), as assessed by questionnaire.
Has a negative pregnancy test (women), no clinically significant abnormalities in blood and urine, and free of traces of drugs.
No history of clinically relevant psychiatric illness.
No previous history of drug or alcohol abuse.
Not a current smoker.
No history of brain injury or of learning disability.
No previous adverse reaction to sleep deprivation, jet lag, shift work or any of the drugs to be administered.
Not vision or hearing impairment unless corrected back to normal.
No endocrine disorder (no abnormal thyroid function tests; no abnormal morning blood cortisol; no primary gonadal disease as indicated by serum LH or FSH concentration \> 10 or \> 15 IU/L, respectively; and no hyperprolactinemia indicated by prolactin \> 25 μg/L).
No sleep or circadian disorder.
Has good habitual sleep with regular bedtimes (between 6 and 10 hours in duration).
Not extreme morning- nor extreme evening-type using Horne-Ostberg Morningness-Eveningness criteria.
No travel across time zones within one month of entering the study.
No shift work within three months of entering the study.
No anemia (hematocrit \<38% in men, \<34% in women).
No blood donation within the previous 8 weeks.
No concurrent participation in another research study.

Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
Sleep and Performance Research Center Coordinator of this site? Confirm its status	Spokane	United States	Recruiting

This page is information, not medical advice. Discuss any trial with your doctor.