NCT07495449Completed
Effect of Infusion Warming on Mannitol Infusion Pain in Patients With Acute Ocular Hypertension
Effect of Intravenous Infusion Warming on Pain, Comfort, Phlebitis, and Intraocular Pressure Outcomes During Mannitol Infusion in Patients With Acute Ocular Hypertension: A Randomized Controlled Study
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
Acute ocular hypertension is a common ophthalmic emergency that often requires rapid reduction of intraocular pressure. Intravenous mannitol is widely used for this purpose, but infusion-related pain and local venous irritation may reduce patient comfort, interfere with infusion speed, and affect treatment experience. This randomized controlled study aims to evaluate whether use of an infusion warming device during intravenous mannitol administration can reduce infusion-related pain, improve patient comfort, decrease local infusion-related complications, and improve infusion efficiency and short-term intraocular pressure outcomes in patients with acute ocular hypertension. Participants with acute ocular hypertension who required intravenous mannitol treatment were randomly assigned to either a warming group or a non-warming group. In the warming group, mannitol was administered using an infusion warming device; in the non-warming group, mannitol was administered according to routine practice without warming. Outcomes included peak pain score during infusion, comfort score, infusion rate, infusion duration, local infusion-related adverse reactions, and intraocular pressure change after treatment.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 142 (actual)
- First submitted
- 17 Mar 2026
- Start date
- 9 Jan 2025
- Primary completion date
- 27 Jul 2025
- Lead sponsor
- Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
- Diseases
- Glaucoma, High blood pressure
- NCT number
- NCT07495449
What you commit to
- Study type: Interventional
- Participants enrolled: 142
- From 9 Jan 2025 to the primary completion date, 27 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients receiving infusion of heat-sensitive fluids or medications for which infusion warming was not appropriate
Other illness
- Severe cognitive impairment, communication difficulty, or other conditions preventing reliable assessment of pain or comfort
- Failure to complete key study outcome assessments
Other
- Patients who did not require intravenous mannitol treatment
- Known contraindication to intravenous mannitol treatment according to routine clinical practice
- Refusal to participate in the study
Who the study is looking for
- Patients with acute ocular hypertension requiring intravenous mannitol treatment in the ophthalmology setting
- Age 18 years or older
- Conscious and able to communicate pain and comfort during infusion
- Able to provide informed consent personally or via a legally authorized representative when appropriate
- Able to complete study-related assessments during and shortly after mannitol infusion
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong Coordinator of this site? Confirm its status | Shantou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.