NCT07496918RecruitingPhase 2
Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)
Pilot Study to Evaluate Feasibility of Sensory Stimulation With Gamma Frequency Entrainment
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
Despite the huge healthcare and economic impact of AD, there is still no disease modifying therapeutics available. In fact, the available therapeutics show low efficacy at best in the treatment of cognitive impairment in dementia. Development of a non-invasive medical device that is effective in slowing cognitive impairment is not only revolutionary but also possibly cost- effective. In this study, participants will come to MIT for a 1-day visit and the investigators will evaluate the effects of GENUS in cognitively normal, healthy adults. Investigators will use Electroencephalogram (EEG), Magnetoencephalography (MEG), magnetic resonance imaging (MRI), neuropsychological testing, and blood sampling in subsets of participants to evaluate for biological effects and safety of GENUS stimulation.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 9 Jan 2025
- Start date
- 20 Feb 2018
- Primary completion date
- 30 Jan 2027
- Lead sponsor
- Massachusetts Institute of Technology
- Diseases
- Alzheimer disease
- NCT number
- NCT07496918
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 150
- From 20 Feb 2018 to the primary completion date, 30 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of seizure or medical diagnosis of epilepsy.
- Have MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body.
Other
- Under the discretion of the site investigator, the site investigator feels the subject cannot complete sufficient key study procedures. Exceptions to these guidelines may be considered on a case-by-case basis at the discretion of the Project Director.
Who the study is looking for
- Have adequate visual and auditory acuity for visual and auditory stimulation to allow for neuropsychological testing.
- Be able to comply with neuropsychological testing and other study procedures in opinion of site PI.
Age in the registry: 18 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| MIT Coordinator of this site? Confirm its status | Cambridge | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.