NCT07497230Completed
Asymmetric High-Flow Nasal Cannula During Pulmonary Rehabilitation in COPD
Feasibility and Preliminary Effects of Asymmetric High-flow Nasal Cannula During Exercise-based Pulmonary Rehabilitation in Patients With COPD: a Randomized Pilot Trial
Source: ClinicalTrials.gov · Last updated 1 Apr 2026
Brief summary (registry, in English)
This randomized pilot trial evaluated the feasibility and preliminary effects of using asymmetric high-flow nasal cannula (A-HFNC) during exercise-based pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary disease (COPD). Thirty patients were randomly assigned to conventional PR or PR supplemented with A-HFNC during aerobic training, completing 12 supervised sessions. The study assessed whether A-HFNC could be safely and acceptably incorporated into PR, and whether it enabled higher training intensity and improved exercise performance. Results showed that the intervention was feasible and safe, with 83% adherence in both groups and no adverse events. Patients in the A-HFNC group trained at significantly higher treadmill inclination and showed a clinically meaningful trend toward greater improvement in maximal exercise tolerance. These findings support the design of a larger definitive trial.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 30 (actual)
- First submitted
- 22 Mar 2026
- Start date
- 2 May 2025
- Primary completion date
- 20 Sept 2025
- Lead sponsor
- Universidad de Santiago de Chile
- Diseases
- COPD
- NCT number
- NCT07497230
What you commit to
- Study type: Interventional
- Participants enrolled: 30
- From 2 May 2025 to the primary completion date, 20 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled respiratory symptoms or any acute condition compromising clinical stability
- Neuromuscular or osteoarticular conditions limiting physical activity
Other
- Acute respiratory exacerbation within the preceding three months
- Current use of home non-invasive mechanical ventilation or artificial airway
- Hospitalization within the preceding three months
- Cognitive or communication difficulties precluding adherence to instructions
- Recent acute cardiovascular events
- Decompensated comorbidities
Who the study is looking for
- Age 40 years or older
- Spirometry-confirmed COPD diagnosis (post-bronchodilator FEV1/FVC ratio less than 0.70)
- Modified Medical Research Council (mMRC) dyspnea grade 2 or higher
- Spirometry performed within the preceding 12 months
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Clínico San José Coordinator of this site? Confirm its status | Santiago | Chile | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.