NCT07498777Not yet recruiting
Individual Alpha Frequency-Based rTMS for Post-Stroke Motor Recovery: Efficacy and Neurophysiological Mechanisms
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the efficacy of a personalized brain stimulation technique, Individual Alpha Frequency (IAF)-based rTMS, for motor function recovery in adult patients with a first-ever ischemic stroke. The main questions it aims to answer are: 1. Does IAF-based rTMS improve upper and lower limb motor recovery better than a sham (placebo) stimulation? 2. How does this personalized stimulation affect brain wave activity (cortical oscillatory dynamics) as measured by EEG? Researchers will compare active IAF-based rTMS with a sham stimulation control in a crossover design to see if the active treatment leads to better clinical motor outcomes and beneficial changes in brain activity. Participants will: 1. Be randomly assigned to one of two sequences: receiving two weeks of active IAF-rTMS followed by two weeks of sham stimulation, or vice versa. 2. Attend 30-minute brain stimulation sessions, targeted at the motor cortex, 5 days a week for a total of 4 weeks. 3. Undergo clinical motor function assessments (including NIHSS, FMA-UE, and FMA-LE) and EEG recordings at three time points: at baseline, after 2 weeks, and at the end of the 4-week study.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 34 (estimated)
- First submitted
- 17 Mar 2026
- Start date
- 1 Apr 2026
- Primary completion date
- 30 Dec 2027
- Lead sponsor
- National Taiwan University Hospital
- Diseases
- Stroke
- NCT number
- NCT07498777
What you commit to
- Study type: Interventional
- Planned participants: 34
- From 1 Apr 2026 to the primary completion date, 30 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Known previous peripheral nerve injury or peripheral neuropathy on the affected side that impairs mobility
- Patients currently using anti-epileptic drugs
Other illness
- Unstable condition
- Stroke primarily caused by cancer-related hypercoagulability or autoimmune diseases (e.g., systemic lupus erythematosus, antiphospholipid syndrome)
- Individual history of epilepsy
- Presence of cardiac pacemakers, cochlear implants, drug delivery pumps, implantable cardioverter-defibrillators, implanted neurostimulators, or other metal objects in the body. This also includes patients who have undergone cranioplasty or have other implanted devices incompatible with rTMS
- Use of tricyclic antidepressants or other medications that may lower the seizure threshold
- Family history of epilepsy
- Patients with brain injuries that may affect the seizure threshold
- Patients who develop sleep disorders during the course of rTMS treatment
- Patients with severe heart disease or patients with uncontrolled migraines caused by increased intracranial pressure
Other
- Hemorrhagic transformation in the brain
- Pregnancy
- Multiple sclerosis patient
- Severe alcoholism
- Hamilton Depression Rating Scale suicide item score ≥ 2
- Patients with skin lesions or damage at the intended site of stimulation.
Who the study is looking for
- Age \>18
- First ischemic stroke patient, confirmed by brain MRI
- Has not received repetitive transcranial magnetic stimulation (rTMS) treatment after this stroke episode
- Cortical, subcortical infarction with motor impairment
- Baseline ADL intact (Full score of pre-stroke Barthel Index)
- Clear consciousness and with the ability to understand and cooperate with the study
- NIHSS 5-20, or FMA-UE 20-50, or FMA-LE 15-25
- Within 2 to 12 weeks after stroke onset
- Participants had received stable treatment prior to the trial or were evaluated by a physician as having an inadequate response to conventional rehabilitation therapy
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of neurology, National Taiwan Univeristy Hospital Yunlin branch Coordinator of this site? Confirm its status | Douliu | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.