NCT07498894Completed
Salivary and Serum Inflammatory Biomarkers in Diabetic Nephropathy by Periodontal Status
Salivary and Serum Inflammatory Biomarkers Based on Periodontal Status in Individuals With Diabetic Nephropathy
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
Chronic inflammation underlies the bidirectional relationship between diabetes and periodontitis, a process that may be further exacerbated in the presence of diabetic nephropathy. While the roles of inflammatory cytokines such as TNF-α and IL-10 in both periodontal tissue destruction and diabetes-related microvascular complications remain unclear, NGAL is recognized as a biomarker for diabetic nephropathy but its association with periodontal disease is not well established. This study aimed to comparatively evaluate salivary and serum levels of NGAL, TNF-α, and IL-10 according to different periodontal conditions in individuals with newly diagnosed diabetes and those with diabetic nephropathy.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 126 (actual)
- First submitted
- 23 Mar 2026
- Start date
- 10 Jun 2024
- Primary completion date
- 12 Dec 2025
- Lead sponsor
- Pamukkale University
- Diseases
- Chronic kidney disease, Type 2 diabetes
- NCT number
- NCT07498894
What you commit to
- Study type: Observational
- Participants enrolled: 126
- From 10 Jun 2024 to the primary completion date, 12 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of systemic antibiotics or anti-inflammatory drugs within the 6 months prior to study enrollment
- Periodontal treatment within the previous 6 months
Other illness
- History of malignancy
- Type 1 diabetes mellitus, gestational diabetes mellitus, or secondary diabetes mellitus
Other
- Having fewer than 15 natural teeth
- Pregnancy or lactation
Who the study is looking for
- Newly diagnosed diabetes: Diagnosed with type 2 diabetes mellitus for less than 5 years and the absence of any diabetic vascular complications
- Diabetic nephropathy: Urinary albumin-to-creatinine ratio \>30 mg/g
Age in the registry: 20 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pamukkale University Faculty of Dentistry Coordinator of this site? Confirm its status | Denizli | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.