NCT07499037Not yet recruitingPhase 2
Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO
Low-dose Versus Standard-dose Anticoagulation With Argatroban and Enoxaparin During Extracorporeal Membrane Oxygenation Controlled by Anti-IIa and An-ti-Xa, Respectively
Source: ClinicalTrials.gov · Last updated 2 Apr 2026
Brief summary (registry, in English)
The standard and most common therapy is anticoagulation with heparin according to activated partial thromboplastin time (aPTT) during extracorporeal membrane oxygenation (ECMO) support. The study will focus on evaluating the efficacy and safety of new anticoagulants on ECMO, namely argatroban and enoxaparin in lower doses controlled according to targeted antiIIa and antiXa markers.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 18 Mar 2026
- Start date
- Jan 2027
- Primary completion date
- Sept 2029
- Lead sponsor
- University Hospital Ostrava
- Diseases
- Heart failure
- NCT number
- NCT07499037
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 200
- From Jan 2027 to the primary completion date, Sept 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Enrolment in the lung transplant program at Motol University Hospital
Other illness
- Known hypersensitivity to the components of the evaluated products
- Allergic reaction to the active ingredients of the evaluated products
Other
- Pregnancy and breastfeeding
Who the study is looking for
- ECMO support with anticoagulation using argatroban/enoxaparin
- Age ≥ 18 years
- Obtaining informed consent in accordance with the procedure specified in the protocol
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Ostrava Coordinator of this site? Confirm its status | Ostrava | Czechia | Unknown status |
| University Hospital Motol Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.