NCT07501702Active, not recruitingPhase 2
A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study With a Long-term Extension of Povetacicept in Adults With Generalized Myasthenia Gravis
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 34 (actual)
- First submitted
- 24 Mar 2026
- Start date
- 13 May 2026
- Primary completion date
- 2 Mar 2029
- Lead sponsor
- Vertex Pharmaceuticals Incorporated
- Diseases
- Myasthenia gravis
- NCT number
- NCT07501702
- EU CT number
- 2025-523950-15-01
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 34
- From 13 May 2026 to the primary completion date, 2 Mar 2029
- 31 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of thymic surgery within 6 months of screening
- History of malignancy within the last 5 years
Other
- Additional exclusion criteria are defined in the protocol
- Other protocol defined Inclusion/Exclusion criteria will apply.
Who the study is looking for
- Age greater than or equal to (\>=) 18 years
- Diagnosis of generalized myasthenia gravis with generalized muscle weakness and fitting MGFA clinical classification II-IV
- Additional inclusion criteria are defined in the protocol
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (31)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Eastern Health - Box Hill Hospital Coordinator of this site? Confirm its status | Box Hill | Australia | Unknown status |
| University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Unknown status |
| St. George's University Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Northern Care Alliance NHS Foundation Trust - Salford Royal Hospital Coordinator of this site? Confirm its status | Salford | United Kingdom | Unknown status |
| Medicover Integrated Clinical Services Sp. z o.o. Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Recruiting |
| Neurologia Śląska Centrum Medyczne Coordinator of this site? Confirm its status | Katowice | Poland | Recruiting |
| Ilkowski I Partnerzy sp.p. Lekarzy Coordinator of this site? Confirm its status | Poznan | Poland | Recruiting |
| Clinical Research Center Sp z o o Medic R Sp k Coordinator of this site? Confirm its status | Poznan | Poland | Recruiting |
| Twoja Przychodnia Poznanskie Centrum Medyczne Sp. z o.o. Coordinator of this site? Confirm its status | Poznan | Poland | Recruiting |
| ETG Neuroscience Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| Centrum Medyczne NeuroProtect Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| Neurology Offices Coordinator of this site? Confirm its status | Boca Raton | United States | Unknown status |
| SFM Clinical Reseach, LLC Coordinator of this site? Confirm its status | Boca Raton | United States | Unknown status |
| Univ of NC Chapel Hill, Neurology Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Clinical Trials of South Carolina - Neurology Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Ut Erlanger Neurology Coordinator of this site? Confirm its status | Chattanooga | United States | Unknown status |
| Homestead Associates in Research Coordinator of this site? Confirm its status | Homestead | United States | Unknown status |
| Hawaii Pacific Neuroscience Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Nerve and Muscle Center of Texas - Neurology Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| UF Health Jacksonville Respiratory Therapy (PFT and DLCO) Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Las Vegas Neurology Center Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Y & L Advance Health Care, Inc D/B/A Elite Clinical Research - Neurology Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Quantix Research Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Tri Valley Neurology Medical Associates, Inc. Coordinator of this site? Confirm its status | Mission Hills | United States | Unknown status |
| HSHS Medical Group - St. Elizabeth's Hospital Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| Texas Institute for Neurological Disorders Coordinator of this site? Confirm its status | Sherman | United States | Unknown status |
| Patient Care Clinical Research, LLC Coordinator of this site? Confirm its status | Snellville | United States | Unknown status |
| USF Carol and Frank Morsani Center for Advanced Healthcare Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Neurology Care Clinic Coordinator of this site? Confirm its status | Waxahachie | United States | Unknown status |
| Istanbul University Medical Faculty Coordinator of this site? Confirm its status | Fatih | Turkey (Türkiye) | Unknown status |
| Kocaeli University Medical Faculty Coordinator of this site? Confirm its status | Kocaeli | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.