NCT07503210Active, not recruitingPhase 3
AMAZE 12: A research study investigating how well the medicine NNC0487-0111 helps people with excess body weight maintain their weight loss
Efficacy and safety of NNC0487-0111s.c once weekly in participants with obesity who have reached target dose during run-in period (AMAZE12).
Source: EU CTIS (euclinicaltrials.eu) · Last updated 2 Nov 2026
Brief summary (registry, in English)
To confirm superiority of NNC0487-0111 CCI versus placebo on change in body weight in participants with obesity
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 325 (estimated)
- First submitted
- 12 Jan 2026
- Start date
- 28 Apr 2026
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- EU CT number
- 2025-523804-62-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 325
- 47 sites in 8 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues within CCI before screening.
Other illness
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
Lab values
- Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol/mol) as measured by the central laboratory at screening.
Who the study is looking for
- Male or female (sex at birth).
- Age between 18 CCI years CCI at the time of signing informed consent.
- Body Mass Index (BMI) ≥ CCI kg/m2.
- CCI
Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers
Sites (47)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Anima Coordinator of this site? Confirm its status | Alken | Belgium | Active, not recruiting |
| Anima Coordinator of this site? Confirm its status | Diepenbeek | Belgium | Active, not recruiting |
| Algemeen Ziekenhuis Groeninge Coordinator of this site? Confirm its status | Kortrijk | Belgium | Active, not recruiting |
| Centre Hospitalier Universitaire de Liège Coordinator of this site? Confirm its status | Liège | Belgium | Active, not recruiting |
| Diagnostic Consultative Center - 1 Lom EOOD Coordinator of this site? Confirm its status | Lom | Bulgaria | Active, not recruiting |
| Outpatient Center For Individual Practice For Specialized Outpatient Medical Care In Endocrinology And Diseases Of The Mutual System Endo Med Consult 2020 - Dr. Alexander Botushanov Coordinator of this site? Confirm its status | Plovdiv | Bulgaria | Active, not recruiting |
| University Multiprofile Hospital For Active Treatment Kaspela EOOD Coordinator of this site? Confirm its status | Plovdiv | Bulgaria | Active, not recruiting |
| MBAL Med Line Clinic AD Coordinator of this site? Confirm its status | Plovdiv | Bulgaria | Active, not recruiting |
| Specialized Obstetrics And Gynecology Hospital For Active Treatment Dr. Shterev EOOD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Active, not recruiting |
| Alexandrovska University Hospital Coordinator of this site? Confirm its status | Sofia | Bulgaria | Active, not recruiting |
| Outpatient Clinic For Individual Practice For Specialized Medical Care Dr. Traykovska EOOD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Active, not recruiting |
| Medical Center Maria Med EOOD Coordinator of this site? Confirm its status | Sofiya | Bulgaria | Active, not recruiting |
| Diabeteszentrum Hamburg West (DZHW) Coordinator of this site? Confirm its status | Hamburg | Germany | Active, not recruiting |
| Eugastro GmbH Coordinator of this site? Confirm its status | Leipzig | Germany | Active, not recruiting |
| Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz Coordinator of this site? Confirm its status | Lingen | Germany | Active, not recruiting |
| Institut fuer Diabetesforschung Muenster GmbH Coordinator of this site? Confirm its status | Muenster | Germany | Active, not recruiting |
| R.E.D. Institut fuer medizinische Studien und Fortbildung GmbH Coordinator of this site? Confirm its status | Oldenburg in Holstein | Germany | Active, not recruiting |
| Diabetologikum - Diabetologische Schwerpunktpraxis Dr. Thomas Segiet Coordinator of this site? Confirm its status | Speyer | Germany | Active, not recruiting |
| Zentrum für klinische Studien Alexander Segner Coordinator of this site? Confirm its status | St. Ingbert-Oberwürzbach | Germany | Active, not recruiting |
| Esbjerg Og Grindsted Sygehus Coordinator of this site? Confirm its status | Esbjerg | Denmark | Active, not recruiting |
| Region Sjaelland Coordinator of this site? Confirm its status | Koege | Denmark | Active, not recruiting |
| Sanos A/S Coordinator of this site? Confirm its status | Vejle | Denmark | Active, not recruiting |
| Centro Periférico de Especialidades Bola Azul Coordinator of this site? Confirm its status | Almería | Spain | Active, not recruiting |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Area De Salud De Leon Y El Bierzo Coordinator of this site? Confirm its status | Leon | Spain | Active, not recruiting |
| Hospital Clínico San Carlos Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Virgen de la Victoria Coordinator of this site? Confirm its status | Málaga | Spain | Active, not recruiting |
| Hospital Universitario Quironsalud Madrid Coordinator of this site? Confirm its status | Pozuelo de Alarcón | Spain | Active, not recruiting |
| University Hospital Virgen Del Rocio S.L. Coordinator of this site? Confirm its status | Sevilla | Spain | Active, not recruiting |
| University Hospital Of Clermont-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Active, not recruiting |
| Centre Hospitalier Universitaire Grenoble Alpes Coordinator of this site? Confirm its status | Grenoble Cedex 9 | France | Active, not recruiting |
| Groupe Sos Sante Coordinator of this site? Confirm its status | Le Creusot | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Lille Coordinator of this site? Confirm its status | Lille | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Active, not recruiting |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico Coordinator of this site? Confirm its status | Bologna | Italy | Active, not recruiting |
| University Hospital Of Ferrara Coordinator of this site? Confirm its status | Ferrara | Italy | Active, not recruiting |
| IRCCS Ospedale Policlinico San Martino Coordinator of this site? Confirm its status | Genoa | Italy | Active, not recruiting |
| Azienda Ospedaliera di Padova Coordinator of this site? Confirm its status | Padova | Italy | Active, not recruiting |
| Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Coordinator of this site? Confirm its status | Palermo | Italy | Active, not recruiting |
| Istituti Clinici Scientifici Maugeri S.p.A. Societa' Benefit In Forma Abbreviata Istituti Clinici Scientifici Maugeri S.p.A. Sb O Anche Ics Maugeri S.p.A. Sb O Maugeri S.p.A. Sb Coordinator of this site? Confirm its status | Pavia | Italy | Active, not recruiting |
| Humanitas Mirasole S.p.A. Coordinator of this site? Confirm its status | Rozzano | Italy | Active, not recruiting |
| Azienda Ospedaliera Universitaria Integrata Verona Coordinator of this site? Confirm its status | Verona | Italy | Active, not recruiting |
| EB FlevoResearch B.V. Coordinator of this site? Confirm its status | Almere | Netherlands | Active, not recruiting |
| Meander Medisch Centrum Coordinator of this site? Confirm its status | Amersfoort | Netherlands | Active, not recruiting |
| Rijnstate Ziekenhuis Stichting Coordinator of this site? Confirm its status | Arnhem | Netherlands | Active, not recruiting |
| PreCare Trial & Recruitment B.V. Coordinator of this site? Confirm its status | Born | Netherlands | Active, not recruiting |
| Brain Research Center Den Bosch B.V. Coordinator of this site? Confirm its status | 's-Hertogenbosch | Netherlands | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.