NCT07507500RecruitingPhase 4
Dual Antiplatelet Therapy Strategies After Acute Myocardial Infarction Undergoing PCI: Prasugrel vs Ticagrelor & 12 Months vs 1-3 Months
Strategies for Antiplatelet Management Following Acute Coronary Syndrome
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
This study is testing different blood-thinning treatment strategies for people who have had a heart attack and were successfully treated with a coronary stent procedure (PCI). All strategies tested are already approved for this condition and used inversally. This study will define which of the approved strategies is the best one. After PCI, patients usually receive two antiplatelet medicines for up to 12 months to help prevent another heart attack or stroke, but this treatment can also increase bleeding risk. This study will compare a shorter course of dual antiplatelet therapy followed by one antiplatelet medicine alone versus the standard 12-month course. In addition, the study will compare two commonly used antiplatelet drugs, prasugrel and ticagrelor. The goal is to find out which strategy best prevents death, heart attack, or stroke while minimizing serious bleeding. This study is not testing any new intervention, rather comparing approved drugs and approved durations of use.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 8100 (estimated)
- First submitted
- 27 Mar 2026
- Start date
- 2 Sept 2026
- Primary completion date
- Jul 2029
- Lead sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
- Diseases
- Coronary artery disease
- NCT number
- NCT07507500
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 8100
- From 2 Sept 2026 to the primary completion date, Jul 2029
- 5 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Indication for oral anticoagulation therapy.
- Prior history of ischaemic or haemorrhagic stroke or transient ischaemic attack.
- Concomitant use of potent CYP3A inhibitors or inducers.
- Planned elective surgery that cannot be deferred 12 months before randomization, requiring interruption of antiplatelet therapy.
Other illness
- Intolerance, contraindication or known allergy to either aspirin, prasugrel or ticagrelor.
- Patients with active bleeding or known bleeding disorders.
- Patients with chronic kidney disease requiring dialysis.
- Any disorder that may interfere with drug absorption.
- Any medical condition that, in the investigator´s judgment, would seriously limit life expectancy (less than one year)
Other
- Patients with known moderate or severe hepatic dysfunction (Child-Pugh Class B or Class C).
- Known intracranial aneurism, arteriovenous malformation or neoplasm.
- Pregnancy or current lactation.
- Active participation in other clinical trials.
Who the study is looking for
- ≥18 years old
- Admitted because of an acute MI (either STEMI or NSTEMI).
- Invasive management during index admission with successful PCI.
- Able to consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fundación Jiménez Díaz University Hospital Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Mater Private Network Dublin Coordinator of this site? Confirm its status | Dublin | Ireland | Not yet recruiting |
| Paula Stradiņa Klīniskā Universitātes Slimnīca Coordinator of this site? Confirm its status | Riga | Latvia | Not yet recruiting |
| Oslo University Hospital Ullevål Coordinator of this site? Confirm its status | Oslo | Norway | Not yet recruiting |
| Saint John Paul II Hospital in Cracow Coordinator of this site? Confirm its status | Krakow | Poland | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.