NCT07508943Not yet recruiting
Decision-making and Optimization of Ventilatory Support for AECOPD Patients
Source: ClinicalTrials.gov · Last updated 2 Apr 2026
Brief summary (registry, in English)
The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The main questions it aims to answer are: 1. How are different respiratory support modalities selected for patients with AECOPD in real-world practice? 2. What clinical patterns are associated with escalation, de-escalation, switching, or discontinuation of respiratory support during hospitalization? Researchers will review de-identified hospital records of patients admitted with AECOPD and analyze the dynamic use of respiratory support during hospitalization, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, non-invasive ventilation, and invasive mechanical ventilation. Participants will not receive any study-assigned intervention. The study will use existing clinical data collected during routine inpatient care and will not change diagnosis, treatment, or follow-up.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 20 Mar 2026
- Start date
- 18 Mar 2026
- Primary completion date
- 18 Mar 2029
- Lead sponsor
- Sir Run Run Shaw Hospital
- Diseases
- COPD
- NCT number
- NCT07508943
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 18 Mar 2026 to the primary completion date, 18 Mar 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients admitted primarily for other acute conditions, including but not limited to pneumonia without documented AECOPD, acute heart failure, pulmonary embolism, pneumothorax, asthma exacerbation, trauma, or postoperative care.
Other
- Patients whose hospitalization was not primarily due to acute exacerbation of COPD, even if COPD was documented as a comorbidity.
- Patients with stable COPD and no evidence of acute exacerbation during the index hospitalization.
- Patients with insufficient documentation to confirm AECOPD as the primary reason for admission.
- Patients with incomplete clinical records preventing retrospective analysis.
- Repeated hospitalizations of the same patient during the study period, with only the first eligible admission included.
Who the study is looking for
- Hospitalized patients with a documented diagnosis of acute exacerbation of chronic obstructive pulmonary disease.
- Patients identified retrospectively from hospital records during the predefined study period.
- Patients who received at least one form of respiratory support during the index hospitalization, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, noninvasive ventilation, or invasive mechanical ventilation.
- Patients with available clinical records containing sufficient dynamic physiological, laboratory, and treatment-related data for retrospective analysis.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sir Run Run Shaw Hospital Zhejiang University School of Medicine Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.