NCT07510048Recruiting
Combatting HIV Or Other STIs Early (CHOOSE)
Combatting HIV Or Other STIs Early (CHOOSE): An Integrated Strategy of Pre-Exposure Prophylaxis (PrEP) Mobile Health (mHealth) Support and Doxycycline Post-Exposure Prophylaxis (DoxyPEP)
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
The overarching goal of this project is to optimize the PrEP Choice integrated mHealth package and assess the efficacy and cost of PrEP Choice on PrEP initiation and adherence among young people. It is hypothesized that PrEP Choice will improve HIV PrEP uptake and adherence among young people and will be cost-effective to deliver to young people in the United States (U.S.). This study will also assess the uptake, adherence, and acceptability of DoxyPEP among young people.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 24 Feb 2026
- Start date
- 16 Sept 2026
- Primary completion date
- 30 Mar 2029
- Lead sponsor
- Westat
- Diseases
- HIV
- NCT number
- NCT07510048
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 16 Sept 2026 to the primary completion date, 30 Mar 2029
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently participating in an interventional trial of PrEP agents, or prior enrollment in HPTN 083, HPTN 083-01, or any other study of long-acting PrEP (including PURPOSE- 2 lenacapavir study);
- Any concurrent participation in other clinical trials or behavioral intervention studies without prior approval from the protocol team.
Other illness
- In a mutually monogamous sexual relationship with a partner not living with HIV for the past 12 months;
- Any other medical, behavioral, or other conditions that in the opinion of the SC Project Lead could interfere with adherence to study procedures or the individual's ability to remain in the study for an 18-month period or compromise interpretation of study results.
Other
- Female;
- Plan to move within 18 months to an area inaccessible to a participating ATN SC;
- An employee of the participating SC; or
Who the study is looking for
- Age 13-24 years, inclusive;
- Self-reports being at increased likelihood for HIV acquisition, defined as having anal sex with a male in their lifetime;
- Owns an iOS or Android Smartphone and able to access all elements of the PrEP Choice package;
- Not currently on PrEP and interested in learning more about PrEP;
- Is not living with HIV;
- Weighs at least 35 kg;
- Willing to receive PrEP care from a provider at a participating ATN SC;
- Able to understand, read, and speak English;
- Able to participate at the study site; and
- Willing and able to provide written informed consent.
- If of legal age or otherwise able to provide independent informed consent as determined by local law and consistent with IRB policies: Willing and able to provide written informed consent for study participation.
- If not of legal age or otherwise not able to provide independent informed consent as determined by local law and consistent with IRB policies: Parent or legal guardian is willing and able to provide written informed consent for study participation and potential participant is willing and able to provide written assent for study participation.
Age in the registry: 13 years to 24 years · Sex: Male · Accepts healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Illinois Chicago Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| St. Jude Children's Research Hospital Coordinator of this site? Confirm its status | Memphis | United States | Recruiting |
| Tulane University Coordinator of this site? Confirm its status | New Orleans | United States | Recruiting |
| San Francisco Department of Public Health Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
| University of South Florida Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| Children's National Medical Center Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.