NCT07512037Not yet recruiting
Burden-Evaluated Active Therapy for AF Using Continuous Wearables BEAT-AF Trial
Source: ClinicalTrials.gov · Last updated 6 Apr 2026
Brief summary (registry, in English)
Traditional AF classification (e.g., paroxysmal, persistent, permanent) relies largely on patient-reported symptoms and intermittent electrocardiographic monitoring, which cannot continuously or objectively reflect disease progression, nor effectively inform optimal intervention timing. Although "AF burden" (i.e., duration of AF episodes) has emerged as a potential marker, its association with clinical outcomes remains inconsistent due to limitations in monitoring methods and its one-dimensional nature. Based on our previous work, investigators developed a five-dimensional AF progression model using photoplethysmography (PPG) signals collected from wearable devices. This model quantifies AF progression across five domains: episode frequency, duration, temporal aggregation, circadian rhythm, and tachycardia burden, enabling continuous and multidimensional assessment. Prior validation has demonstrated high agreement with 24-hour Holter monitoring and effective identification of high-risk patients. The BEAT-AF trial is designed to evaluate the clinical utility of this model in a real-world setting. Specifically, investigators will investigate whether early intervention (e.g., optimization of medical therapy or consideration of catheter ablation) in patients with elevated five-dimensional AF burden (≥4.59%) can reduce symptoms, rhythm/rate-related abnormalities, and AF-related adverse events (such as stroke and heart failure). This study is expected to provide new evidence for dynamic monitoring of AF progression, optimal timing of intervention, and personalized management strategies, ultimately improving patient outcomes.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 3194 (estimated)
- First submitted
- 23 Mar 2026
- Start date
- Apr 2026
- Primary completion date
- Jun 2028
- Lead sponsor
- Navy General Hospital, Beijing
- Diseases
- Atrial fibrillation
- NCT number
- NCT07512037
What you commit to
- Study type: Interventional
- Planned participants: 3194
- From Apr 2026 to the primary completion date, Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Has an implanted pacemaker, implantable cardioverter-defibrillator or cardiac resynchronization therapy device.
- There may be skin diseases, limb deformities or allergies that prevent the proper wearing of wearable devices on the upper limbs.
- Having active mental disorders or cognitive impairments, as well as other conditions that result in lack of or restricted ability to act, and which, in the judgment of the researchers, make it impossible for the subject to comply with the trial protocol.
Other
- During pregnancy, lactation, or planning to become pregnant during the trial period.
- At the same time, participate in other clinical trials that may interfere with the results of this study
Who the study is looking for
- Inpatients ≥18 years of age at admission;
- Paroxysmal atrial fibrillation was diagnosed;
- Own a smart phone and a smart watch and be able to operate them basically;
- Before being enrolled, the average daily atrial fibrillation burden was calculated to be ≥ 4.59% based on monitoring through an intelligent wristwatch for at least 3 days;
- The treatment status meets any of the following conditions:
- If anticoagulation therapy is being administered, the treatment plan must be stable for at least 4 weeks;
- If heart rate or rhythm control medications are being used, the treatment plan must be stable for at least 4 weeks;
- Or no specific rhythm control treatment for atrial fibrillation is being received;
- Sign the informed consent form
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sixth Medical Center of Chinese PLA General Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.