NCT07512453Not yet recruiting
Study in Patients With Osteoporosis and Fragility Fractures to Estimate the Extent and Impact of Delayed Administration of Anti-fracture Therapy
Retrospective Multicenter Study in Patients With Osteoporosis and Fragility Fractures to Estimate the Extent and Impact of Delayed Administration of Anti-fracture Therapy
Source: ClinicalTrials.gov · Last updated 6 Apr 2026
Brief summary (registry, in English)
Osteoporosis (OP) and fragility fractures are a significant problem that leads to morbidity, mortality, and high costs for the National Health System. The treatment of fragility fractures includes numerous anti-resorptive and anabolic drugs, and its goal is the secondary prevention of new fractures. It is well known that the risk of a new fracture following a fracture event is highest in the months immediately following the first fracture. However, recent data clearly show a dramatic global delay in the administration of anti-osteoporotic therapy following a fragility fracture. It has been estimated that in Italy, 71% of patients with fragility fractures eligible for anti-fracture treatment did not receive timely treatment (a problem defined as a "treatment gap"), and that in 2034, the incidence of new fragility fractures will increase compared to 2019 \[1\]. However, there is a lack of real-life Italian data on the extent of the treatment gap in osteoporotic patients with fragility fractures and its impact in terms of the incidence of subsequent fragility fractures: this study therefore aims to fill this gap by collecting data from a large population of patients attending several centers throughout the country.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 8000 (estimated)
- First submitted
- 13 Mar 2026
- Start date
- 1 Apr 2026
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Azienda Ospedaliero, Universitaria Pisana
- Diseases
- Osteoporosis
- NCT number
- NCT07512453
What you commit to
- Study type: Observational
- Planned participants: 8000
- From 1 Apr 2026 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- no previous fragility fractures - failure to sign the consent form Exit criteria
Age
- patients under the age of 18
Who the study is looking for
- adult patients of both sexes;
- patients with osteoporosis and/or previous fragility fractures (fragility fractures are defined as those that occur spontaneously, i.e., not resulting from trauma, even of low intensity, or those caused by a fall from standing height.
- willingness to sign the consent form
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| AOUP Stabilimento di Santa Chiara - UO Endocrinologia Coordinator of this site? Confirm its status | Pisa | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.