NCT07514377Active, not recruiting
JiGenerations Health Cohort Study：Parental Exposure and Intergenerational Health in China
A Population-based Prospective Cohort Study Aimed at Examining the Effects of Parental Exposure Before and During Pregnancy on Adverse Pregnancy Outcomes, Offspring Health, and Mental Development for Chinese Ethnics
Source: ClinicalTrials.gov · Last updated 7 Apr 2026
Brief summary (registry, in English)
The growing recognition of maternal health's impact on offspring necessitates large-scale prospective cohort studies spanning the maternal-child life cycle. This study establishes a family-centered birth cohort of 100,000 Chinese participants, tracking from preconception through offspring adolescence to investigate early-life health trajectories and intergenerational transmission of diseases, health status, and psychological-behavioral patterns. Data collection includes biospecimens (placenta, cord blood, breast milk, blood, urine, feces) and multi-omics analysis (genomic, proteomic, metabolomic, microbiomic), alongside clinical information from preconception, pregnancy, birth through childhood (0-14 years). The cohort covers 24 stratified sites across China, incorporating real-time environmental monitoring (air pollution, meteorological data) and sociogeographic factors. Targeting reproductive-age couples (18-45 years) and their offspring, the study addresses multigenerational health linkages, urban-rural disparities, and regional diversity from 2025 to 2039. By integrating genetic, environmental and lifestyle data, this research will identify critical intervention windows and mechanisms for chronic disease transmission across generations, supporting China's "Healthy China" initiative and developing targeted strategies for population health and aging.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100000 (actual)
- First submitted
- 16 Nov 2025
- Start date
- 1 Aug 2025
- Primary completion date
- 31 Dec 2039
- Lead sponsor
- National Research Institute for Family Planning, China
- Diseases
- Obesity, Fatty liver disease (MASLD/MASH)
- NCT number
- NCT07514377
What you commit to
- Study type: Observational
- Participants enrolled: 100000
- From 1 Aug 2025 to the primary completion date, 31 Dec 2039
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Intellectual disability or other serious mental disorders;
- Suffering from serious underlying diseases and may have a significant impact on pregnancy outcome;
Other
- Those with poor compliance and difficulty in follow-up.
Who the study is looking for
- Parental Generation: Eligible participants include couples of reproductive age who undergo free pre-pregnancy eugenic health examinations, or pregnant women registered for prenatal care at healthcare institutions during early pregnancy (≤14 weeks). The participants are aged 18-45 years old and have mobile phones and internet (computer) devices. All participants must provide informed consent and commit to long-term follow-up. The participants have no serious neuropsychiatric disorders, with sufficient understanding and expression to complete the survey.
- Offspring Generation: Newborns whose parents participated in pre-pregnancy eugenic health checks and/or maternal prenatal examinations are enrolled in the cohort upon parental (guardian) consent. Designated hospitals will provide expedited medical services, free physical examinations, free child healthcare, and free psychological counseling to ensure comprehensive follow-up spanning infancy, preschool, school age, and early adolescence (0-14 years).
Age in the registry: 1 day to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Research Institute for Family Planning Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.