NCT07514611Recruiting
Weight Loss Via Intelligent Guidance in Patients With Coronary Heart Disease and Obesity: a Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 12 May 2026
Brief summary (registry, in English)
Coronary Heart Disease (CHD) is an ischemic heart disease caused by coronary atherosclerosis, and it is the leading cause of death from cardiovascular diseases worldwide. Weight loss in obese patients can significantly improve metabolic indicators such as dyslipidemia and insulin resistance; therefore, weight loss may become a target for improving the prognosis of obese patients with coronary heart disease. This study is a multicenter, randomized controlled clinical trial aimed at evaluating the effect of software-based healthy weight loss guidance (personalized diet + exercise intervention) in obese patients with coronary heart disease. It is expected that 136 patients will be enrolled in hospitals including Guangdong Provincial People's Hospital, with a total study duration of 1 year.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 140 (estimated)
- First submitted
- 10 Mar 2026
- Start date
- 18 Apr 2026
- Primary completion date
- 31 Jul 2028
- Lead sponsor
- Guangdong Provincial People's Hospital
- Diseases
- Obesity, Coronary artery disease
- NCT number
- NCT07514611
What you commit to
- Study type: Interventional
- Planned participants: 140
- From 18 Apr 2026 to the primary completion date, 31 Jul 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unstable angina pectoris or acute myocardial infarction occurring within the previous month;
Other illness
- Comorbid endocrine or neurological diseases, cancer, or a history of bariatric surgery that affect body weight; or long-term use of medications that impact body weight;
- Comorbid diseases that affect exercise capacity, such as severe cardiopulmonary diseases or osteoarthritic conditions;
- Comorbid diseases that affect diet, such as severe mental disorders, bulimia or anorexia nervosa, or cognitive dysfunction;
Lab values
- Significant liver or kidney dysfunction, defined as: glomerular filtration rate \< 60 ml/(min·1.73m²) or undergoing dialysis; alanine transaminase (ALT) or aspartate transaminase (AST) ≥ 3 times the upper limit of the normal range specified by the research center;
Other
- Severe language, psychological, or physical disabilities that prevent participation in the protocol;
- Pregnant or lactating women, or individuals of childbearing potential who are unwilling/unable to use effective contraceptive measures;
- Participation in other interventional clinical trials;
- Body weight change exceeding 5% within the past year;
- Patients with a habit of long-term high-intensity exercise(more than 2 sessions per week of high-intensity endurance training, or more than 3 sessions per week of moderate-intensity endurance training);
- Patients deemed unsuitable for participation in the study by the researchers.
Who the study is looking for
- Age range: 18-65 years old .
- History of coronary heart disease confirmed by coronary angiography or coronary CTA, showing ≥50% stenosis in at least one major coronary artery (left main coronary artery, left anterior descending artery, left circumflex artery, right coronary artery); or a definite history of myocardial infarction, or prior coronary revascularization (PCI or CABG).
- BMI: Body Mass Index (BMI) ≥ 28 kg/m²
- Weight loss willingness: Has the intention to lose weight
- Smartphone proficiency: Able to use a smartphone.
- Daily living ability: Capable of performing basic activities of daily living independently.
- Informed consent: Voluntarily participates in the study, signs a written informed consent form, and is willing to cooperate with follow-up
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Guangdong Provincial People's Hospital Coordinator of this site? Confirm its status | Guangzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.