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NCT07514962Recruiting

Minimally Invasive Coronary Artery Bypass Supported by Cangrelor

Source: ClinicalTrials.gov · Last updated 14 Apr 2026

Brief summary (registry, in English)

The purpose of this study is to find out whether it is safe and practical to perform MIDCAB surgery (a minimally invasive heart bypass procedure) while patients receive a continuous cangrelor infusion during the operation. Cangrelor is a medicine that helps prevent blood clots and works quickly through a vein drip. The study compares patients receiving cangrelor during surgery to patients who had the same surgery in the past while on aspirin, with or without cangrelor given beforehand. Study Question: Can MIDCAB surgery be safely performed under cangrelor infusion, without increasing the risk of bleeding or other complications? Hypothesis: Using cangrelor during MIDCAB surgery is safe and feasible, and it provides effective protection against blood clots during the procedure. This study will help doctors understand whether intraoperative cangrelor can improve patient safety and outcomes in minimally invasive heart surgery.

Status (registry)
Recruiting
Study type
Observational
Enrollment
30 (estimated)
First submitted
25 Mar 2026
Start date
12 May 2024
Primary completion date
1 Jan 2028
Lead sponsor
Cardiocentro Ticino
NCT number
NCT07514962

What you commit to

  • Study type: Observational
  • Planned participants: 30
  • From 12 May 2024 to the primary completion date, 1 Jan 2028
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Administration of fibrinolytics or GP IIb/IIIa inhibitors
  • Previous intracranial hemorrhage
  • Patients undergoing concomitant PCI and MIDCAB
  • Recent administration of fibrinolytics or GP IIb/IIIa inhibitors
  • Previous intracranial hemorrhage
  • Patients undergoing concomitant PCI and MIDCAB

Other illness

  • Known bleeding diathesis
  • Severe renal or liver disease
  • Known hypersensitivity to study drug (cangrelor)
  • Known bleeding diathesis
  • Severe renal or liver disease

Other

  • Pregnancy or breast feeding
  • Unconsciousness
  • Pregnancy or breast feeding

Who the study is looking for

  • Age ≥18 years old
  • CABG with IMA-LAD graft in MIDCAB technique
  • Age ≥18 years old
  • CABG with IMA-LAD graft in MIDCAB technique
  • Signed informed consent

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Istituto Cardiocentro Ticino
Coordinator of this site? Confirm its status
LuganoSwitzerlandRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.