NCT07522502Completed
Metabolic and Immunoinflammatory Profiles in Adults With Newly Diagnosed Diabetes
Clinical, Metabolic, and Immunoinflammatory Characteristics of Adult-Onset Diabetes at Diagnosis: A Cross-Sectional Study in the Kazakh Population
Source: ClinicalTrials.gov · Last updated 10 Sept 2026
Brief summary (registry, in English)
The goal of this observational study is to better understand how diabetes develops in adults at the time of diagnosis. The study focuses on adults with newly diagnosed diabetes in the Kazakh population. The main questions it aims to answer are: * How do insulin resistance and beta-cell function differ between participants? * How is the immune system involved at the early stage of diabetes? * How are inflammation markers related to metabolic changes? Participants undergo clinical and laboratory assessments at diagnosis. These include: * Measurement of body mass index (BMI) and blood glucose control (HbA1c) * Assessment of insulin resistance and beta-cell function using HOMA2 indices * Measurement of C-peptide levels * Testing for islet autoantibodies (GADA, IA-2A, ZnT8A, ICA) * Measurement of inflammatory markers, including interleukin-1 beta (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra) This study aims to improve understanding of different forms of adult-onset diabetes and support more personalized approaches to diagnosis and treatment.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 240 (actual)
- First submitted
- 25 Mar 2026
- Start date
- 1 May 2024
- Primary completion date
- 1 Jan 2025
- Lead sponsor
- West Kazakhstan Marat Ospanov Medical University
- Diseases
- Type 1 diabetes, Type 2 diabetes
- NCT number
- NCT07522502
What you commit to
- Study type: Observational
- Participants enrolled: 240
- From 1 May 2024 to the primary completion date, 1 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of long-term insulin therapy prior to enrollment
Other illness
- Clinical features suggestive of classical type 1 diabetes at presentation
- Severe acute illness or infection at the time of assessment
Lab values
- Incomplete clinical or laboratory data
Other
- Pregnancy
Who the study is looking for
- Adults aged 25 years and older
- Kazakh population with newly diagnosed diabetes mellitus
- Diagnosis established in routine clinical practice
- No prior insulin therapy at the time of enrollment
- No prior use of glucose-lowering therapy beyond initial management
- Ability and willingness to provide informed consent
Age in the registry: 25 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| West Kazakhstan Marat Ospanov Medical University Coordinator of this site? Confirm its status | Aktobe | Kazakhstan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.